Applications of Cucurbiturils in Medicinal Chemistry and Chemical Biology

Debapratim Das; Khaleel I. Assaf; Khaleel I. Assaf; Werner M. Nau

doi:10.3389/fchem.2019.00619

Frontiers in Chemistry (Sep 2019)

Applications of Cucurbiturils in Medicinal Chemistry and Chemical Biology

Debapratim Das,
Khaleel I. Assaf,
Khaleel I. Assaf,
Werner M. Nau

Affiliations

Debapratim Das: Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, India
Khaleel I. Assaf: Department of Life Sciences and Chemistry, Jacobs University Bremen, Bremen, Germany
Khaleel I. Assaf: Department of Chemistry, Faculty of Science, Al-Balqa Applied University, Al-Salt, Jordan
Werner M. Nau: Department of Life Sciences and Chemistry, Jacobs University Bremen, Bremen, Germany

DOI: https://doi.org/10.3389/fchem.2019.00619
Journal volume & issue: Vol. 7

Abstract

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The supramolecular chemistry of cucurbit[n]urils (CBn) has been rapidly developing to encompass diverse medicinal applications, including drug formulation and delivery, controlled drug release, and sensing for bioanalytical purposes. This is made possible by their unique recognition properties and very low cytotoxicity. In this review, we summarize the host-guest complexation of biologically important molecules with CBn, and highlight their implementation in medicinal chemistry and chemical biology.

Published in Frontiers in Chemistry

ISSN: 2296-2646 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://journal.frontiersin.org/journal/chemistry

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