Transdermal permeation of curcumin promoted by choline geranate ionic liquid: Potential for the treatment of skin diseases

Rodrigo Boscariol; José M. Oliveira Junior; Denicezar A. Baldo; Victor M. Balcão; Marta M.D.C. Vila

Saudi Pharmaceutical Journal (Apr 2022)

Transdermal permeation of curcumin promoted by choline geranate ionic liquid: Potential for the treatment of skin diseases

Rodrigo Boscariol,
José M. Oliveira Junior,
Denicezar A. Baldo,
Victor M. Balcão,
Marta M.D.C. Vila

Affiliations

Rodrigo Boscariol: PhageLab – Laboratory of Biofilms and Bacteriophages, University of Sorocaba, 18023-000 Sorocaba, SP, Brazil
José M. Oliveira Junior: PhageLab – Laboratory of Biofilms and Bacteriophages, University of Sorocaba, 18023-000 Sorocaba, SP, Brazil
Denicezar A. Baldo: PhageLab – Laboratory of Biofilms and Bacteriophages, University of Sorocaba, 18023-000 Sorocaba, SP, Brazil
Victor M. Balcão: PhageLab – Laboratory of Biofilms and Bacteriophages, University of Sorocaba, 18023-000 Sorocaba, SP, Brazil; Department of Biology and CESAM, University of Aveiro, Campus Universitário de Santiago, P-3810-193 Aveiro, Portugal; Corresponding authors at: Universidade de Sorocaba (UNISO), PhageLab, Cidade Universitária Prof. Aldo Vannucchi, Rod. Raposo Tavares km 92.5, CEP 18023-000 Sorocaba/SP, São Paulo, Brazil.
Marta M.D.C. Vila: PhageLab – Laboratory of Biofilms and Bacteriophages, University of Sorocaba, 18023-000 Sorocaba, SP, Brazil; Corresponding authors at: Universidade de Sorocaba (UNISO), PhageLab, Cidade Universitária Prof. Aldo Vannucchi, Rod. Raposo Tavares km 92.5, CEP 18023-000 Sorocaba/SP, São Paulo, Brazil.

Journal volume & issue: Vol. 30, no. 4
pp. 382 – 397

Abstract

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The transdermal permeation of curcumin aided by choline and geranic acid ionic liquid (CAGE-IL) was addressed as a potential treatment for skin diseases. An in-depth analysis of the effect of CAGE-IL concentration in the enhancement of transdermal permeation of curcumin was performed, and the results were modelled via nonlinear regression analysis. The results obtained showed that a low percentage of CAGE-IL (viz. 2.0%, w/w) was effective in disrupting the skin structure in a transient fashion, facilitating the passage of curcumin dissolved in it.

Published in Saudi Pharmaceutical Journal

ISSN: 1319-0164 (Print)
Publisher: Elsevier
Country of publisher: Saudi Arabia
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/saudi-pharmaceutical-journal/

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