Nature Communications (Jun 2017)
A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis
- Sebastian Dütting,
- Frederique Gaits-Iacovoni,
- David Stegner,
- Michael Popp,
- Adrien Antkowiak,
- Judith M.M. van Eeuwijk,
- Paquita Nurden,
- Simon Stritt,
- Tobias Heib,
- Katja Aurbach,
- Oguzhan Angay,
- Deya Cherpokova,
- Niels Heinz,
- Ayesha A. Baig,
- Maximilian G. Gorelashvili,
- Frank Gerner,
- Katrin G. Heinze,
- Jerry Ware,
- Georg Krohne,
- Zaverio M. Ruggeri,
- Alan T. Nurden,
- Harald Schulze,
- Ute Modlich,
- Irina Pleines,
- Cord Brakebusch,
- Bernhard Nieswandt
Affiliations
- Sebastian Dütting
- Institute of Experimental Biomedicine, University Hospital and University of Würzburg
- Frederique Gaits-Iacovoni
- INSERM UMR1048, Institut des Maladies Métaboliques et Cardiovasculaires—I2MC, UMR1048, Institut National de la Santé et de la Recherche Médicale, Université de Toulouse
- David Stegner
- Institute of Experimental Biomedicine, University Hospital and University of Würzburg
- Michael Popp
- Institute of Experimental Biomedicine, University Hospital and University of Würzburg
- Adrien Antkowiak
- INSERM UMR1048, Institut des Maladies Métaboliques et Cardiovasculaires—I2MC, UMR1048, Institut National de la Santé et de la Recherche Médicale, Université de Toulouse
- Judith M.M. van Eeuwijk
- Institute of Experimental Biomedicine, University Hospital and University of Würzburg
- Paquita Nurden
- Institute of Experimental Biomedicine, University Hospital and University of Würzburg
- Simon Stritt
- Institute of Experimental Biomedicine, University Hospital and University of Würzburg
- Tobias Heib
- Institute of Experimental Biomedicine, University Hospital and University of Würzburg
- Katja Aurbach
- Institute of Experimental Biomedicine, University Hospital and University of Würzburg
- Oguzhan Angay
- Rudolf Virchow Center, University of Würzburg
- Deya Cherpokova
- Institute of Experimental Biomedicine, University Hospital and University of Würzburg
- Niels Heinz
- Research Group for Gene Modification in Stem Cells, LOEWE Center for Cell and Gene Therapy Frankfurt/Main and the Paul-Ehrlich-Institute
- Ayesha A. Baig
- Institute of Experimental Biomedicine, University Hospital and University of Würzburg
- Maximilian G. Gorelashvili
- Institute of Experimental Biomedicine, University Hospital and University of Würzburg
- Frank Gerner
- Institute of Experimental Biomedicine, University Hospital and University of Würzburg
- Katrin G. Heinze
- Rudolf Virchow Center, University of Würzburg
- Jerry Ware
- Department of Physiology and Biophysics, University of Arkansas for Medical Sciences
- Georg Krohne
- Biocenter, University of Würzburg
- Zaverio M. Ruggeri
- Department of Molecular Medicine, The Scripps Research Institute
- Alan T. Nurden
- Institut Hospitalo-Universitaire LIRYC, Plateforme Technologique d’Innovation Biomédicale, Hôpital Xavier Arnozan
- Harald Schulze
- Institute of Experimental Biomedicine, University Hospital and University of Würzburg
- Ute Modlich
- Research Group for Gene Modification in Stem Cells, LOEWE Center for Cell and Gene Therapy Frankfurt/Main and the Paul-Ehrlich-Institute
- Irina Pleines
- Institute of Experimental Biomedicine, University Hospital and University of Würzburg
- Cord Brakebusch
- BRIC, Biomedical Institute, University of Copenhagen
- Bernhard Nieswandt
- Institute of Experimental Biomedicine, University Hospital and University of Würzburg
- DOI
- https://doi.org/10.1038/ncomms15838
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Platelets derive from large precursor cells (megakaryocytes) in the bone marrow. Düttinget al. show that megakaryocyte polarization and platelet biogenesis in the bone-marrow sinusoids are directed by adhesion receptor GPIb signalling and resulting balanced antagonism between RhoA (stop-signal) and Cdc42 (go-signal).
