iScience (Sep 2022)
Pathogenic mechanisms involving the interplay between adipose tissue and auto-antibodies in rheumatoid arthritis
- Iván Arias-de la Rosa,
- Alejandro Escudero-Contreras,
- Miriam Ruiz-Ponce,
- Laura Cuesta-López,
- Cristóbal Román-Rodríguez,
- Carlos Pérez-Sánchez,
- Patricia Ruiz-Limón,
- Rocío Guzman- Ruiz,
- Fernando Leiva-Cepas,
- Juan Alcaide,
- Pedro Segui,
- Chamaida Plasencia,
- Ana Martinez-Feito,
- Pilar Font,
- María C. Ábalos,
- Rafaela Ortega,
- María M. Malagón,
- Francisco J. Tinahones,
- Eduardo Collantes-Estévez,
- Chary López-Pedrera,
- Nuria Barbarroja
Affiliations
- Iván Arias-de la Rosa
- GENYO (Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, PTS Granada, Granada, Spain; Corresponding author
- Alejandro Escudero-Contreras
- Rheumatology Service/Department of Medical and Surgical Sciences, Maimonides Institute for Biomedicine Research of Cordoba (IMIBIC)/ /University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain
- Miriam Ruiz-Ponce
- Rheumatology Service/Department of Medical and Surgical Sciences, Maimonides Institute for Biomedicine Research of Cordoba (IMIBIC)/ /University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain
- Laura Cuesta-López
- Rheumatology Service/Department of Medical and Surgical Sciences, Maimonides Institute for Biomedicine Research of Cordoba (IMIBIC)/ /University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain
- Cristóbal Román-Rodríguez
- Rheumatology Service/Department of Medical and Surgical Sciences, Maimonides Institute for Biomedicine Research of Cordoba (IMIBIC)/ /University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain
- Carlos Pérez-Sánchez
- Rheumatology Service/Department of Medical and Surgical Sciences, Maimonides Institute for Biomedicine Research of Cordoba (IMIBIC)/ /University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain
- Patricia Ruiz-Limón
- Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga University, Málaga, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain
- Rocío Guzman- Ruiz
- Department of Cell Biology, Physiology, and Immunology, Maimonides Institute for Biomedical Research of Cordoba (IMIBIC)/University of Córdoba/Reina Sofía University Hospital, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain
- Fernando Leiva-Cepas
- Department of Pathology, Reina Sofia University Hospital, Cordoba, Spain
- Juan Alcaide
- Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga University, Málaga, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain
- Pedro Segui
- Radiology Service, Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Cordoba, Spain
- Chamaida Plasencia
- Rheumatology Department, La Paz University Hospital, Madrid, Spain
- Ana Martinez-Feito
- Immunorheumatology Department, IDIPAZ, Madrid, Spain
- Pilar Font
- Rheumatology Service/Department of Medical and Surgical Sciences, Maimonides Institute for Biomedicine Research of Cordoba (IMIBIC)/ /University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain
- María C. Ábalos
- Rheumatology Service/Department of Medical and Surgical Sciences, Maimonides Institute for Biomedicine Research of Cordoba (IMIBIC)/ /University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain
- Rafaela Ortega
- Rheumatology Service/Department of Medical and Surgical Sciences, Maimonides Institute for Biomedicine Research of Cordoba (IMIBIC)/ /University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain
- María M. Malagón
- Department of Cell Biology, Physiology, and Immunology, Maimonides Institute for Biomedical Research of Cordoba (IMIBIC)/University of Córdoba/Reina Sofía University Hospital, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain
- Francisco J. Tinahones
- Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga University, Málaga, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain
- Eduardo Collantes-Estévez
- Rheumatology Service/Department of Medical and Surgical Sciences, Maimonides Institute for Biomedicine Research of Cordoba (IMIBIC)/ /University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain
- Chary López-Pedrera
- Rheumatology Service/Department of Medical and Surgical Sciences, Maimonides Institute for Biomedicine Research of Cordoba (IMIBIC)/ /University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain
- Nuria Barbarroja
- Rheumatology Service/Department of Medical and Surgical Sciences, Maimonides Institute for Biomedicine Research of Cordoba (IMIBIC)/ /University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain; Corresponding author
- Journal volume & issue
-
Vol. 25,
no. 9
p. 104893
Abstract
Summary: We aimed to evaluate the association between adipose tissue (AT) dysfunction, autoimmunity, and disease activity in rheumatoid arthritis (RA). A cross-sectional study including 150 RA patients and 50 healthy donors and longitudinal study with 122 RA patients treated with anti-tumor necrosis factor (TNF)-α, anti-interleukin 6 receptor (IL6R) or anti-CD20 therapies for 6 months were carried out. In vitro experiments with human AT and adipocyte and macrophage cell lines were performed. A collagen-induced arthritis mouse model was developed. The insulin resistance and the altered adipocytokine profile were associated with disease activity, the presence of anti-citrullinated proteins anti-bodies (ACPAs), and worse response to therapy in RA. AT in the context of arthritis is characterized by an inflammatory state alongside the infiltration of macrophages and B/plasmatic cells, where ACPAs can have a direct impact, inducing inflammation and insulin resistance in macrophages and promoting a defective adipocyte differentiation, partially restored by biologicals.
