Cognitive Control, Not Time, Determines the Status of Items in Working Memory

Abstract

Despite the fact that multiple items can be held in working memory (WM), it is often the case that only one of these is relevant for guiding in-the-moment behavior. Therefore, understanding how priority is established and controlled in WM is an important problem. Data from Rose et al. (2016) have provided evidence that although neuroimaging evidence for an active trace of an “unprioritized memory item” (UMI) held in WM drops to baseline levels, evidence for its retention in WM can be “reactivated” by a single pulse of transcranial magnetic stimulation (TMS). Critically, this TMS-reactivation effect was specific to the first delay period of a dual serial retrocue (DSR) task, when the UMI could be needed for the trial’s second memory probe, and was not observed during the second delay period, when the uncued item was no longer needed (i.e., when it is an “irrelevant memory item” [IMI]). A problem for the interpretation of these results, however, is that the status of the UMI/IMI was confounded with time spent in WM, as well as with the number of intervening cognitive operations. Here, we report data from a follow-up study designed to replicate the findings Rose et al. (2016) and to add a condition that unconfounds time-since-sample-presentation and UMI/IMI status. The results indicate that the TMS-reactivation effect is, indeed, an index of status in WM (UMI vs. IMI), and not a mere consequence of time elapsed since sample presentation.

Keywords

• working memory
• cognitive control
• tms