Pathology and Laboratory Medicine International (Dec 2023)

Serum Lipids, Insulin-Like Growth Factor Binding Protein-3 and Treatment Outcomes in Women with and without Cervical Lesions in South Western Uganda: A Cohort Study

  • Ssedyabane F,
  • Randall TC,
  • Tusubira D,
  • Castro CM,
  • Najjuma JN,
  • Okeny C,
  • Nuwashaba D,
  • Mudondo H,
  • Kajabwangu R,
  • Muhumuza J,
  • Namuli A,
  • Ngonzi J

Journal volume & issue
Vol. Volume 15
pp. 91 – 105

Abstract

Read online

Frank Ssedyabane,1 Thomas C Randall,2 Deusdedit Tusubira,3 Cesar M Castro,4,5 Josephine Nambi Najjuma,6 Christopher Okeny,1 Doreen Nuwashaba,1 Hope Mudondo,1 Rogers Kajabwangu,7 Joy Muhumuza,7 Alexcer Namuli,7 Joseph Ngonzi7 1Department of Medical Laboratory Science, Mbarara University of Science of Science and Technology, Mbarara, Uganda; 2Department of Global Health and Social Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; 3Department of Biochemistry, Mbarara University of Science of Science and Technology, Mbarara, Uganda; 4Centre for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; 5Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; 6Department of Nursing, Mbarara University of Science of Science and Technology, Mbarara, Uganda; 7Department of Obstetrics and Gynecology, Mbarara University of Science of Science and Technology, Mbarara, UgandaCorrespondence: Frank Ssedyabane, Email [email protected]: There is a documented association between cervical cancer and metabolic syndrome. In this study, we determined the association between lipids, insulin-like growth factor binding protein-3 (IGFBP-3) and treatment outcomes for cervical lesions at Mbarara Regional Referral Hospital (MRRH) in south western Uganda.Patients and Methods: In this prospective cohort study, we recruited 94 cases and 94 controls at the cervical cancer clinic of MRRH, and followed them for 12 months. Cases were confirmed with cytology and/or histology. With consent, we collected demographic data and measured lipids and IGFBP-3 both at baseline and after 12 months. The lipid profile was measured using a Cobas 6000 Chemistry Analyzer, whereas IGFBP-3 was measured using a MAGLUMI fully automated chemiluminescence immunoassay analyzer. Abnormal values for lipids were defined using WHO recommended cut-offs. IGFBP-3 concentrations were divided into two categories of low concentration (< 3.29 μg/mL) and raised concentration (≥ 3.29 μg/mL). Statistical analyses were conducted in STATA version 17 using logistic regression analysis. A p-value of < 0.05 was taken to be statistically significant.Results: The average (mean ± SD) age of our participants was 38.7± 8.2 years for controls and 34.5± 7.8 years for cases. The average serum IGFBP-3 concentration was 3.769± 1.098 μg/mL among cases with cleared lesions and 3.505± 0.979 μg/mL among cases whose lesions persisted. A serum IGFBP-3 concentration of less than 3.291 μg/mL was likely to be associated with clearance of cervical lesions (AOR 1.65, p=0.67), although this was not statistically significant. A serum triglyceride concentration of 35– 135 mg/dL was also likely to be associated with clearance of cervical lesions (AOR 2.41, p=0.46), although this was also not statistically significant.Conclusion: Although not statistically significant, reduced serum concentrations of IGFBP-3 and triglyceride may be associated with clearance of cervical lesions. Lipid management may be of benefit in the treatment of cervical lesions.Keywords: cervical intraepithelial neoplasia, cervical lesions, clearance, persistence, IGFBP-3

Keywords