Nature Communications (Oct 2022)
Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance
- Ankur Chakravarthy,
- Ian Reddin,
- Stephen Henderson,
- Cindy Dong,
- Nerissa Kirkwood,
- Maxmilan Jeyakumar,
- Daniela Rothschild Rodriguez,
- Natalia Gonzalez Martinez,
- Jacqueline McDermott,
- Xiaoping Su,
- Nagayasau Egawa,
- Christina S. Fjeldbo,
- Vilde Eide Skingen,
- Heidi Lyng,
- Mari Kyllesø Halle,
- Camilla Krakstad,
- Afschin Soleiman,
- Susanne Sprung,
- Matt Lechner,
- Peter J. I. Ellis,
- Mark Wass,
- Martin Michaelis,
- Heidi Fiegl,
- Helga Salvesen,
- Gareth J. Thomas,
- John Doorbar,
- Kerry Chester,
- Andrew Feber,
- Tim R. Fenton
Affiliations
- Ankur Chakravarthy
- Princess Margaret Cancer Centre, University Health Network
- Ian Reddin
- Cancer Sciences, Faculty of Medicine, University of Southampton
- Stephen Henderson
- UCL Cancer Institute, Bill Lyons Informatics Centre, University College London
- Cindy Dong
- School of Biosciences, Division of Natural Sciences, University of Kent
- Nerissa Kirkwood
- School of Biosciences, Division of Natural Sciences, University of Kent
- Maxmilan Jeyakumar
- School of Biosciences, Division of Natural Sciences, University of Kent
- Daniela Rothschild Rodriguez
- School of Biosciences, Division of Natural Sciences, University of Kent
- Natalia Gonzalez Martinez
- School of Biosciences, Division of Natural Sciences, University of Kent
- Jacqueline McDermott
- UCL Cancer Institute, University College London
- Xiaoping Su
- MD Anderson Cancer Center
- Nagayasau Egawa
- Department of Pathology, University of Cambridge
- Christina S. Fjeldbo
- Department of Radiation Biology, Oslo University Hospital
- Vilde Eide Skingen
- Department of Radiation Biology, Oslo University Hospital
- Heidi Lyng
- Department of Radiation Biology, Oslo University Hospital
- Mari Kyllesø Halle
- Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen
- Camilla Krakstad
- Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen
- Afschin Soleiman
- INNPATH, Institute of Pathology, Tirol Kliniken Innsbruck
- Susanne Sprung
- Institute of Pathology, Medical University of Innsbruck
- Matt Lechner
- UCL Cancer Institute, University College London
- Peter J. I. Ellis
- School of Biosciences, Division of Natural Sciences, University of Kent
- Mark Wass
- School of Biosciences, Division of Natural Sciences, University of Kent
- Martin Michaelis
- School of Biosciences, Division of Natural Sciences, University of Kent
- Heidi Fiegl
- Department of Obstetrics and Gynaecology, Medical University of Innsbruck
- Helga Salvesen
- Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen
- Gareth J. Thomas
- Cancer Sciences, Faculty of Medicine, University of Southampton
- John Doorbar
- Department of Pathology, University of Cambridge
- Kerry Chester
- UCL Cancer Institute, University College London
- Andrew Feber
- Centre for Molecular Pathology, Royal Marsden Hospital Trust
- Tim R. Fenton
- Cancer Sciences, Faculty of Medicine, University of Southampton
- DOI
- https://doi.org/10.1038/s41467-022-33544-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Human papillomavirus (HPV) is a known cause of cervical cancer. Here, the authors perform a multi-omic analysis using published cervical squamous cell carcinoma cohorts from the USA, Europe, and SubSaharan Africa and identify two cervical squamous cell carcinoma subtypes that display prognostic differences.
