Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association

Abstract

The mutations induced by activation-induced cytidine deaminase (AID) trigger antibody diversification but can cause genome instability. We find that AID phosphorylation is an important determinant of “off-target” mutagenesis and identify a drug that increases this activity. These studies demonstrate how dysregulating AID phosphorylation can promote oncogenesis.

Keywords

• aicda
• activation-induced cytidine deaminase
• b cells
• class switch recombination
• chromosome translocation
• lithium
• lymphoma
• mutation
• myc