Nature Communications (Jun 2020)

Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice

  • Alexa N. Roth,
  • Emily W. Helm,
  • Carmen Mirabelli,
  • Erin Kirsche,
  • Jonathan C. Smith,
  • Laura B. Eurell,
  • Sourish Ghosh,
  • Nihal Altan-Bonnet,
  • Christiane E. Wobus,
  • Stephanie M. Karst

DOI
https://doi.org/10.1038/s41467-020-16798-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 8

Abstract

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Here the authors show that a murine norovirus causes self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice and show that lymphocytes affect disease in a dual manner. The data suggests that neonatal mice are a promising model for further studies.