PDLIM1 sustains DNA damage response by promoting chromatin relaxation and activating DNA–PK complex

• Yue Lang,
• Dexuan Gao,
• Lan Yu,
• Xiang-Xiang Zhang,
• Debabrata Saha,
• Benjamin P.C. Chen,
• Meng-Meng Gu,
• Zeng-Fu Shang

Affiliations

Yue Lang

Department of Nuclear Medicine, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, China; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China; Corresponding author. Department of Nuclear Medicine, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, China.

Dexuan Gao

Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China

Lan Yu

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

Xiang-Xiang Zhang

State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China

Debabrata Saha

Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

Benjamin P.C. Chen

Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

Meng-Meng Gu

Department of Nuclear Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu 215002, China; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China; Corresponding author. Department of Nuclear Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu 215002, China.

Zeng-Fu Shang

State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Corresponding author. Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.