Synthesis of 6-Methyluracilpentylviologen Resorcinarene Cavitand
Albina Y. Ziganshina,
Elina E. Mansurova,
Marina M. Shulaeva,
Viktor V. Syakaev,
Vyacheslav E. Semenov,
Igor S. Antipin
Affiliations
Albina Y. Ziganshina
A. E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str. 8, Kazan 420088, Russia
Elina E. Mansurova
Alexander Butlerov Institute of Chemistry, Kazan Federal University, Lobachevsky Str. 1/29, Kazan 420008, Russia
Marina M. Shulaeva
A. E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str. 8, Kazan 420088, Russia
Viktor V. Syakaev
A. E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str. 8, Kazan 420088, Russia
Vyacheslav E. Semenov
A. E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str. 8, Kazan 420088, Russia
Igor S. Antipin
Alexander Butlerov Institute of Chemistry, Kazan Federal University, Lobachevsky Str. 1/29, Kazan 420008, Russia
Resorcinarenes, as macrocyclic compounds, are widely used to recognize substrates and create supramolecular assemblies. Their bowl-like form organizes functional groups at the upper and lower rims, which has a substantial impact on the molecular recognition of various substrates. As a result, resorcinarenes make good drug nanocarrier candidates. This paper presents the synthesis of a new resorcinarene cavitand functionalized along the upper rim with methyluracil and viologen fragments for its potential use in drug delivery. Methyluracils and viologens are well-known receptor-targeted compounds capable of facilitating the vector transfer of drugs and increasing the effectiveness of their action on cells. The paper describes the synthesis of resorcinarene modified with methyluracil and viologen groups along with its structure determined by 1H-, 13C-NMR and IR spectroscopy.
