Nature Communications (Sep 2018)
A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines
- Leticia Peris,
- Mariano Bisbal,
- José Martinez-Hernandez,
- Yasmina Saoudi,
- Julie Jonckheere,
- Marta Rolland,
- Muriel Sebastien,
- Jacques Brocard,
- Eric Denarier,
- Christophe Bosc,
- Christophe Guerin,
- Sylvie Gory-Fauré,
- Jean Christophe Deloulme,
- Fabien Lanté,
- Isabelle Arnal,
- Alain Buisson,
- Yves Goldberg,
- Laurent Blanchoin,
- Christian Delphin,
- Annie Andrieux
Affiliations
- Leticia Peris
- GIN, Inserm 1216, Univ. Grenoble Alpes
- Mariano Bisbal
- GIN, Inserm 1216, Univ. Grenoble Alpes
- José Martinez-Hernandez
- GIN, Inserm 1216, Univ. Grenoble Alpes
- Yasmina Saoudi
- GIN, Inserm 1216, Univ. Grenoble Alpes
- Julie Jonckheere
- GIN, Inserm 1216, Univ. Grenoble Alpes
- Marta Rolland
- GIN, Inserm 1216, Univ. Grenoble Alpes
- Muriel Sebastien
- GIN, Inserm 1216, Univ. Grenoble Alpes
- Jacques Brocard
- GIN, Inserm 1216, Univ. Grenoble Alpes
- Eric Denarier
- GIN, Inserm 1216, Univ. Grenoble Alpes
- Christophe Bosc
- GIN, Inserm 1216, Univ. Grenoble Alpes
- Christophe Guerin
- CytoMorpho Lab, UMR5168, Biosciences & Biotechnology Institute of Grenoble, CEA, CNRS, INRA, Univ. Grenoble-Alpes
- Sylvie Gory-Fauré
- GIN, Inserm 1216, Univ. Grenoble Alpes
- Jean Christophe Deloulme
- GIN, Inserm 1216, Univ. Grenoble Alpes
- Fabien Lanté
- GIN, Inserm 1216, Univ. Grenoble Alpes
- Isabelle Arnal
- GIN, Inserm 1216, Univ. Grenoble Alpes
- Alain Buisson
- GIN, Inserm 1216, Univ. Grenoble Alpes
- Yves Goldberg
- GIN, Inserm 1216, Univ. Grenoble Alpes
- Laurent Blanchoin
- CytoMorpho Lab, UMR5168, Biosciences & Biotechnology Institute of Grenoble, CEA, CNRS, INRA, Univ. Grenoble-Alpes
- Christian Delphin
- GIN, Inserm 1216, Univ. Grenoble Alpes
- Annie Andrieux
- GIN, Inserm 1216, Univ. Grenoble Alpes
- DOI
- https://doi.org/10.1038/s41467-018-05869-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Microtubule-associated protein 6 (MAP6) is known to be important for synaptic plasticity and cognition, supposedly via interaction with microtubules. Here, the authors found that MAP6 is crucial for the stabilisation of enlarged synapses through its association with a different cytoskeletal element, actin.
