Nature Communications (Apr 2022)
High failure rate of ChAdOx1-nCoV19 immunization against asymptomatic infection in healthcare workers during a Delta variant surge
- Rajat Ujjainiya,
- Akansha Tyagi,
- Viren Sardana,
- Salwa Naushin,
- Nitin Bhatheja,
- Kartik Kumar,
- Joydeb Barman,
- Satyartha Prakash,
- Rintu Kutum,
- Akash Kumar Bhaskar,
- Prateek Singh,
- Kumardeep Chaudhary,
- Menka Loomba,
- Yukti Khanna,
- Chestha Walecha,
- Rizwan Ahmed,
- Ashutosh Yadav,
- Archana Bajaj,
- Gaurav Malik,
- Sahar Qureshi,
- Swati Waghdhare,
- Samreen Siddiqui,
- Kamal Krishan Trehan,
- Manju Mani,
- Rajiv Dang,
- Poonam Das,
- Pankaj Dougall,
- Monica Mahajan,
- Sudipta Sonar,
- Kamini Jakhar,
- Reema Kumar,
- Mahima Tiwari,
- Shailendra Mani,
- Sankar Bhattacharyya,
- Sandeep Budhiraja,
- Anurag Agrawal,
- Debasis Dash,
- Sujeet Jha,
- Shantanu Sengupta
Affiliations
- Rajat Ujjainiya
- CSIR-Institute of Genomics and Integrative Biology
- Akansha Tyagi
- Department of Clinical Research, Max Super Speciality Hospital, Saket, New Delhi (A Unit of Devki Devi Foundation)
- Viren Sardana
- CSIR-Institute of Genomics and Integrative Biology
- Salwa Naushin
- CSIR-Institute of Genomics and Integrative Biology
- Nitin Bhatheja
- CSIR-Institute of Genomics and Integrative Biology
- Kartik Kumar
- CSIR-Institute of Genomics and Integrative Biology
- Joydeb Barman
- CSIR-Institute of Genomics and Integrative Biology
- Satyartha Prakash
- CSIR-Institute of Genomics and Integrative Biology
- Rintu Kutum
- CSIR-Institute of Genomics and Integrative Biology
- Akash Kumar Bhaskar
- CSIR-Institute of Genomics and Integrative Biology
- Prateek Singh
- CSIR-Institute of Genomics and Integrative Biology
- Kumardeep Chaudhary
- CSIR-Institute of Genomics and Integrative Biology
- Menka Loomba
- Department of Clinical Research, Max Super Speciality Hospital, Saket, New Delhi (A Unit of Devki Devi Foundation)
- Yukti Khanna
- Department of Clinical Research, Max Super Speciality Hospital, Saket, New Delhi (A Unit of Devki Devi Foundation)
- Chestha Walecha
- Department of Clinical Research, Max Super Speciality Hospital, Saket, New Delhi (A Unit of Devki Devi Foundation)
- Rizwan Ahmed
- Department of Clinical Research, Max Super Speciality Hospital, Saket, New Delhi (A Unit of Devki Devi Foundation)
- Ashutosh Yadav
- Institute of Endocrinology, Diabetes, and Metabolism, Max Super Speciality Hospital, Saket, New Delhi (A Unit of Devki Devi Foundation)
- Archana Bajaj
- Max Hospital Shalimar Bagh
- Gaurav Malik
- Max Hospital Shalimar Bagh
- Sahar Qureshi
- Max Smart Super Speciality Hospital
- Swati Waghdhare
- Institute of Endocrinology, Diabetes, and Metabolism, Max Super Speciality Hospital, Saket, New Delhi (A Unit of Devki Devi Foundation)
- Samreen Siddiqui
- Institute of Endocrinology, Diabetes, and Metabolism, Max Super Speciality Hospital, Saket, New Delhi (A Unit of Devki Devi Foundation)
- Kamal Krishan Trehan
- Max Hospital Shalimar Bagh
- Manju Mani
- Max Smart Super Speciality Hospital
- Rajiv Dang
- Max Hospital
- Poonam Das
- Institute of Laboratory Medicine & Transfusion Services, Max Super Speciality Hospital, Saket, New Delhi (A Unit of Devki Devi Foundation)
- Pankaj Dougall
- Max Super Speciality Hospital, Saket, New Delhi (A Unit of Devki Devi Foundation)
- Monica Mahajan
- Max Hospital Panchsheel
- Sudipta Sonar
- Translational Health Science and Technology Institute
- Kamini Jakhar
- Translational Health Science and Technology Institute
- Reema Kumar
- Translational Health Science and Technology Institute
- Mahima Tiwari
- Translational Health Science and Technology Institute
- Shailendra Mani
- Translational Health Science and Technology Institute
- Sankar Bhattacharyya
- Translational Health Science and Technology Institute
- Sandeep Budhiraja
- Department of Internal Medicine, Max Super Speciality Hospital, Saket
- Anurag Agrawal
- CSIR-Institute of Genomics and Integrative Biology
- Debasis Dash
- CSIR-Institute of Genomics and Integrative Biology
- Sujeet Jha
- Institute of Endocrinology, Diabetes, and Metabolism, Max Super Speciality Hospital, Saket, New Delhi (A Unit of Devki Devi Foundation)
- Shantanu Sengupta
- CSIR-Institute of Genomics and Integrative Biology
- DOI
- https://doi.org/10.1038/s41467-022-29404-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 6
Abstract
The authors study a cohort of healthcare workers in India who received two doses of the ChAdOx-1-nCoV19 vaccine during the Delta wave. Using serological data, they infer that 25% of the cohort were infected within 60 days of vaccination, although there were no severe infections leading to hospitalisations.
