EZH2 in Cancer Progression and Potential Application in Cancer Therapy: A Friend or Foe?

Ke-Sin Yan; Chia-Yuan Lin; Tan-Wei Liao; Cheng-Ming Peng; Shou-Chun Lee; Yi-Jui Liu; Wing P. Chan; Ruey-Hwang Chou

doi:10.3390/ijms18061172

International Journal of Molecular Sciences (May 2017)

EZH2 in Cancer Progression and Potential Application in Cancer Therapy: A Friend or Foe?

Ke-Sin Yan,
Chia-Yuan Lin,
Tan-Wei Liao,
Cheng-Ming Peng,
Shou-Chun Lee,
Yi-Jui Liu,
Wing P. Chan,
Ruey-Hwang Chou

Affiliations

Ke-Sin Yan: Graduate Institute of Biomedical Sciences, China Medical University, No.91, Hsueh-Shih Rd., North Dist., Taichung 40402, Taiwan
Chia-Yuan Lin: Graduate Institute of Biomedical Sciences, China Medical University, No.91, Hsueh-Shih Rd., North Dist., Taichung 40402, Taiwan
Tan-Wei Liao: Center for Molecular Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung 40402, Taiwan
Cheng-Ming Peng: Da Vinci Minimally Invasive Surgery Center, Chung Shan Medical University Hospital, No. 110, Sec. 1, Chien-Kuo N. Rd., Taichung 40201, Taiwan
Shou-Chun Lee: Master’s Program of Biomedical Informatics and Biomedical Engineering, Feng Chia University, No. 100, Wenhwa Rd., Seatwen Dist., Taichung 40724, Taiwan
Yi-Jui Liu: Master’s Program of Biomedical Informatics and Biomedical Engineering, Feng Chia University, No. 100, Wenhwa Rd., Seatwen Dist., Taichung 40724, Taiwan
Wing P. Chan: Department of Radiology, Wan Fang Hospital, Taipei Medical University, No. 111, Sec. 3, Singlong Rd., Taipei 11696, Taiwan
Ruey-Hwang Chou: Graduate Institute of Biomedical Sciences, China Medical University, No.91, Hsueh-Shih Rd., North Dist., Taichung 40402, Taiwan

DOI: https://doi.org/10.3390/ijms18061172
Journal volume & issue: Vol. 18, no. 6
p. 1172

Abstract

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Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery. EZH2 functions as a double-facet molecule in regulation of gene expression via repression or activation mechanisms, depending on the different cellular contexts. EZH2 interacts with both histone and non-histone proteins to modulate diverse physiological functions including cancer progression and malignancy. In this review article, we focused on the updated information regarding microRNAs (miRNAs) and long non coding RNAs (lncRNAs) in regulation of EZH2, the oncogenic and tumor suppressive roles of EZH2 in cancer progression and malignancy, as well as current pre-clinical and clinical trials of EZH2 inhibitors.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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