Patient Preference and Adherence (May 2018)
Estimation of population-based utility weights for gastric cancer-related health states
Abstract
Hyeon-Jeong Lee,1 Minsu Ock,2 Kyu-Pyo Kim,3 Min-Woo Jo1 1Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, Korea; 2Department of Preventive Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea; 3Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Background: This study aimed to generate utility weights of gastric cancer-related health states from the perspective of the Korean general population. Methods: The Korean adults (age ≥19 years) included in the study were sampled using multistage quota sampling methods stratified by sex, age, and education level. Nine scenarios for hypothetical gastric cancer-related health states were developed and reviewed. After consenting to participate, the subjects were surveyed by trained interviewers using a computer-assisted personal interview method. Participants were asked to perform standard gamble tasks to measure the utility weights of 5 randomly assigned health states (from among nine scenarios). The mean utility weight was calculated for each health state. Results: Three hundred twenty-six of the 407 adults who completed this study were included in the analysis. The mean utility weights from the standard gamble were 0.857 (no gastric cancer with Helicobacter pylori infection), 0.773 (early gastric cancer [EGC] with endoscopic surgery), 0.779 (EGC with subtotal gastrectomy), 0.767 (EGC with total gastrectomy), 0.602 (advanced gastric cancer with subtotal gastrectomy and adjuvant chemotherapy), 0.643 (advanced gastric cancer with total gastrectomy and adjuvant chemotherapy), 0.522 (advanced gastric cancer with extended gastrectomy and adjuvant chemotherapy), 0.404 (metastatic gastric cancer with palliative chemotherapy), and 0.399 (recurrent gastric cancer with palliative chemotherapy). Conclusion: This study was the first to comprehensively estimate the utility weights of gastric cancer-related health states in a general population. The utility weights derived from this study could be useful for future economic evaluations related to gastric cancer interventions. Keywords: stomach neoplasms, health-related quality of life, utility, population, standard gamble
