Frontiers in Medicine (Feb 2022)
Application of Animal Models in Interpreting Dry Eye Disease
- Jun Zhu,
- Jun Zhu,
- Takenori Inomata,
- Takenori Inomata,
- Takenori Inomata,
- Kendrick Co Shih,
- Yuichi Okumura,
- Yuichi Okumura,
- Kenta Fujio,
- Kenta Fujio,
- Tianxiang Huang,
- Tianxiang Huang,
- Ken Nagino,
- Ken Nagino,
- Yasutsugu Akasaki,
- Yasutsugu Akasaki,
- Keiichi Fujimoto,
- Ai Yanagawa,
- Maria Miura,
- Maria Miura,
- Akie Midorikawa-Inomata,
- Kunihiko Hirosawa,
- Kunihiko Hirosawa,
- Mizu Kuwahara,
- Mizu Kuwahara,
- Hurramhon Shokirova,
- Atsuko Eguchi,
- Yuki Morooka,
- Yuki Morooka,
- Fang Chen,
- Akira Murakami,
- Akira Murakami
Affiliations
- Jun Zhu
- Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Jun Zhu
- Department of Ophthalmology, Northern Jiangsu People's Hospital, Yangzhou, China
- Takenori Inomata
- Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Takenori Inomata
- Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Takenori Inomata
- Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Kendrick Co Shih
- Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
- Yuichi Okumura
- Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Yuichi Okumura
- Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Kenta Fujio
- Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Kenta Fujio
- Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Tianxiang Huang
- Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Tianxiang Huang
- Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Ken Nagino
- Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Ken Nagino
- Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Yasutsugu Akasaki
- Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Yasutsugu Akasaki
- Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Keiichi Fujimoto
- Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Ai Yanagawa
- Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Maria Miura
- Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Maria Miura
- Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Akie Midorikawa-Inomata
- Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Kunihiko Hirosawa
- Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Kunihiko Hirosawa
- Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Mizu Kuwahara
- Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Mizu Kuwahara
- Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Hurramhon Shokirova
- Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Atsuko Eguchi
- Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Yuki Morooka
- Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Yuki Morooka
- Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Fang Chen
- Department of Ophthalmology, Northern Jiangsu People's Hospital, Yangzhou, China
- Akira Murakami
- Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Akira Murakami
- Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
- DOI
- https://doi.org/10.3389/fmed.2022.830592
- Journal volume & issue
-
Vol. 9
Abstract
Different pathophysiologic mechanisms are involved in the initiation, development, and outcome of dry eye disease (DED). Animal models have proven valuable and efficient in establishing ocular surface microenvironments that mimic humans, thus enabling better understanding of the pathogenesis. Several dry eye animal models, including lacrimal secretion insufficiency, evaporation, neuronal dysfunction, and environmental stress models, are related to different etiological factors. Other models may be categorized as having a multifactorial DED. In addition, there are variations in the methodological classification, including surgical lacrimal gland removal, drug-induced models, irradiation impairment, autoimmune antibody-induced models, and transgenic animals. The aforementioned models may manifest varying degrees of severity or specific pathophysiological mechanisms that contribute to the complexity of DED. This review aimed to summarize various dry eye animal models and evaluate their respective characteristics to improve our understanding of the underlying mechanism and identify therapeutic prospects for clinical purposes.
Keywords
