Study of the correlation between ApoB/ApoA1 and vitreous hemorrhage secondary to diabetic retinopathy

Abstract

Objective To investigate the correlation between ApoB/ApoA1 and vitreous hemorrhage （VH） secondary to diabetic retinopathy （DR）. Methods 187 patients with DR from August 2021 to December 2022 were recruited and divided into VH （n=96） and non-VH groups （n=91）. Baseline data were compared between two groups. The risk factors of VH secondary to DR were analyzed by Logistic regression analysis. Results There were no significant differences in age， gender， course of disease， body mass index （BMI）， history of hypertension， smoking and drinking between two groups （all P > 0.05）. In the VH group， fasting plasma glucose （FPG）， glycosylated hemoglobin A1c （HbA1c）， total cholesterol （TC）， high-density lipoprotein cholesterol （HDL-C）， low-density lipoprotein cholesterol （LDL-C）， ApoB/ApoA1 and FIBrinogen （FIB） were significantly higher compared with those in the non-VH group， and the differences were statistically significant （all P < 0.05）， while there were no significant differences in TG， APTT， PT and TT between two groups （all P > 0.05）. HbA1c （OR=1.438 （1.179-1.864））， ApoB/ApoA1 （OR=25.274（5.699~112.092）） and FIB （OR=1.471（1.022~2.118）） were the risk factors for VH （all P < 0.05）. Conclusions HbA1c， ApoB/ApoA1 and FIB are closely related to VH. Monitoring blood glucose， lipid and coagulation and timely intervention can delay the progression of DR and reduce the incidence of VH.

Keywords

• apob/apoa1|diabetic retinopathy|vitreous hemorrhage|blood glucose|blood lipid|coagulation