A case of molecularly profiled extraneural medulloblastoma metastases in a child

Abstract

Abstract Background Extraneural metastases are relatively rare manifestations of medulloblastoma. Case presentation We present the case of a young boy with group three MYCN-amplified medulloblastoma. He received multimodal chemotherapy consisting of gross total resection followed by postoperative craniospinal radiation and adjuvant chemotherapy. The patient developed extraneural metastases 4 months after the end of therapy. Literature review identifies the poor prognosis of MYCN-amplified medulloblastomas as well as extraneural metastases; we review the current limitations and future directions of medulloblastoma treatment options. Conclusion To the best of our knowledge, this is the first molecularly characterized report of extraneural metastases of medulloblastoma in a child.

Keywords

• Extraneural metastasis
• Medulloblastoma
• MYCN-amplified
• NGS
• Methylation