Allogeneic Hematopoietic Stem Cell Transplant Infusion During Venovenous Extracorporeal Membrane Oxygenation Support

Rayan Qutob, MD, SBIM, FCCM; Xinyu Ji, MDCM; Nawaporn Assanangkornchai, MD, FRCPT; Vladimir Sapon-Cousineau, MDCM, FRCPC; May Tam, CCP, CPC; Rita Larotonda, RN; Jean-Pierre Routy, MD, FRCPC; Gizelle Popradi, MDCM, FRCPC; Gordan Samoukovic, MD, MSc, FRCSC

doi:10.1097/CCE.0000000000000551

Critical Care Explorations (Oct 2021)

Allogeneic Hematopoietic Stem Cell Transplant Infusion During Venovenous Extracorporeal Membrane Oxygenation Support

Rayan Qutob, MD, SBIM, FCCM,
Xinyu Ji, MDCM,
Nawaporn Assanangkornchai, MD, FRCPT,
Vladimir Sapon-Cousineau, MDCM, FRCPC,
May Tam, CCP, CPC,
Rita Larotonda, RN,
Jean-Pierre Routy, MD, FRCPC,
Gizelle Popradi, MDCM, FRCPC,
Gordan Samoukovic, MD, MSc, FRCSC

Affiliations

Rayan Qutob, MD, SBIM, FCCM: 1 Department of Critical Care Medicine, McGill University, Montreal, QC, Canada.
Xinyu Ji, MDCM: 3 Department of Internal Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada.
Nawaporn Assanangkornchai, MD, FRCPT: 1 Department of Critical Care Medicine, McGill University, Montreal, QC, Canada.
Vladimir Sapon-Cousineau, MDCM, FRCPC: 5 Department of Hematology, McGill University, Montreal, QC, Canada.
May Tam, CCP, CPC: 6 Perfusion Department, McGill University, Montreal, QC, Canada.
Rita Larotonda, RN: 7 Nursing Department, McGill University, Montreal, QC, Canada.
Jean-Pierre Routy, MD, FRCPC: 5 Department of Hematology, McGill University, Montreal, QC, Canada.
Gizelle Popradi, MDCM, FRCPC: 5 Department of Hematology, McGill University, Montreal, QC, Canada.
Gordan Samoukovic, MD, MSc, FRCSC: 1 Department of Critical Care Medicine, McGill University, Montreal, QC, Canada.

DOI: https://doi.org/10.1097/CCE.0000000000000551
Journal volume & issue: Vol. 3, no. 10
p. e551

Abstract

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BACKGROUND:. Management of hematopoietic stem cell transplant complicated by respiratory failure has been facilitated by the use of extracorporeal membrane oxygenation as a bridge to curative chemotherapeutic options. This is the first report of hematopoietic stem cell transplantation on extracorporeal membrane oxygenation in the adult population. CASE SUMMARY:. A 28-year-old woman diagnosed with idiopathic aplastic anemia complicated by acute respiratory distress syndrome secondary to pneumonia required venovenous extracorporeal membrane oxygenation to supplement oxygenation and ventilation. She received hematopoietic stem cell transplantation while she was on extracorporeal membrane oxygenation support. MAIN RESULTS AND CONCLUSION:. Delivery of the stem cell through extracorporeal membrane oxygenation circuit was successful in the described patient. There was no sequestered stem cell in extracorporeal membrane oxygenation circuit, and she was found to have 90% donor chimerism suggesting successful engraftment. This report showed that infusion of stem cell through extracorporeal membrane oxygenation circuit is safe and feasible, and our results suggest that successful engraftment is possible.

Published in Critical Care Explorations

ISSN: 2639-8028 (Online)
Publisher: Wolters Kluwer
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Medical emergencies. Critical care. Intensive care. First aid
Website: https://journals.lww.com/ccejournal/pages/default.aspx

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