Counteraction between Astrin-PP1 and Cyclin-B-CDK1 pathways protects chromosome-microtubule attachments independent of biorientation

Xinhong Song; Duccio Conti; Roshan L. Shrestha; Dominique Braun; Viji M. Draviam

doi:10.1038/s41467-021-27131-9

Nature Communications (Dec 2021)

Counteraction between Astrin-PP1 and Cyclin-B-CDK1 pathways protects chromosome-microtubule attachments independent of biorientation

Xinhong Song,
Duccio Conti,
Roshan L. Shrestha,
Dominique Braun,
Viji M. Draviam

Affiliations

Xinhong Song: School of Biological and Chemical Sciences, Queen Mary, University of London
Duccio Conti: School of Biological and Chemical Sciences, Queen Mary, University of London
Roshan L. Shrestha: Department of Genetics, University of Cambridge
Dominique Braun: Department of Genetics, University of Cambridge
Viji M. Draviam: School of Biological and Chemical Sciences, Queen Mary, University of London

DOI: https://doi.org/10.1038/s41467-021-27131-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Chromosome instability frequently occurs due to issues with chromosome-microtubule attachments. Here the authors show that the Astrin-PP1 and Cyclin-B-CDK1 pathways counteract each other to protect chromosome-microtubule attachments independent of biorientation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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