Nature Communications (May 2020)

Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas

  • Kimiko Inoue,
  • Narumi Ogonuki,
  • Satoshi Kamimura,
  • Hiroki Inoue,
  • Shogo Matoba,
  • Michiko Hirose,
  • Arata Honda,
  • Kento Miura,
  • Masashi Hada,
  • Ayumi Hasegawa,
  • Naomi Watanabe,
  • Yukiko Dodo,
  • Keiji Mochida,
  • Atsuo Ogura

DOI
https://doi.org/10.1038/s41467-020-16044-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Somatic cell nuclear transfer (SCNT) frequently results in abnormal placenta development in cloned mice. Here the authors show that loss of histone methylation (H3K27me3) imprinting in clustered Sfmbt2 miRNAs contributes to SCNT placenta defect.