Association of TNF-α 308G/A and LEPR Gln223Arg Polymorphisms with the Risk of Type 2 Diabetes Mellitus

Maria Trapali; Dimitra Houhoula; Anthimia Batrinou; Anastasia Kanellou; Irini F. Strati; Argyris Siatelis; Panagiotis Halvatsiotis

doi:10.3390/genes13010059

Genes (Dec 2021)

Association of TNF-α 308G/A and LEPR Gln223Arg Polymorphisms with the Risk of Type 2 Diabetes Mellitus

Maria Trapali,
Dimitra Houhoula,
Anthimia Batrinou,
Anastasia Kanellou,
Irini F. Strati,
Argyris Siatelis,
Panagiotis Halvatsiotis

Affiliations

Maria Trapali: Department of Biomedical Medicine, University of West Attica, 12243 Attiki, Greece
Dimitra Houhoula: Department of Food Science and Technology, University of West Attica, 12243 Attiki, Greece
Anthimia Batrinou: Department of Food Science and Technology, University of West Attica, 12243 Attiki, Greece
Anastasia Kanellou: Department of Food Science and Technology, University of West Attica, 12243 Attiki, Greece
Irini F. Strati: Department of Food Science and Technology, University of West Attica, 12243 Attiki, Greece
Argyris Siatelis: 3rd Department of Urologist Medical School, National and Kapodistrian University of Athens, “ATTIKON” University Hospital, 12462 Chaidari, Greece
Panagiotis Halvatsiotis: 2nd Propaedeutic Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, “ATTIKON” University Hospital, 12462 Chaidari, Greece

DOI: https://doi.org/10.3390/genes13010059
Journal volume & issue: Vol. 13, no. 1
p. 59

Abstract

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The objective of the present study was to identify the association of the TNF-α- 308G/A and leptin receptor (LEPR) Gln223Arg polymorphisms with the risk of development of type 2 diabetes mellitus (T2DM). Methods: A total of 160 volunteers were studied: 108 with T2DM and 52 participants as control, who served as the control group. Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) for the genomic region of TNF-α- 308G/A and LEPR Gln223Arg were carried out. Results: The frequency of LEPR Gln223Arg genotypes in T2DM and control groups showed significant differences in the distribution of genotypes (p TNF-α- 308G/A genotypes in T2DM and control subjects showed significant differences in the distribution of genotypes (p p < 0.05).

Published in Genes

ISSN: 2073-4425 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Genetics
Website: http://www.mdpi.com/journal/genes/

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