Nature Communications (Jun 2021)

RPA shields inherited DNA lesions for post-mitotic DNA synthesis

  • Aleksandra Lezaja,
  • Andreas Panagopoulos,
  • Yanlin Wen,
  • Edison Carvalho,
  • Ralph Imhof,
  • Matthias Altmeyer

DOI
https://doi.org/10.1038/s41467-021-23806-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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Single-stranded DNA during DNA replication and repair in S/G2 needs protection by replication protein A (RPA). Here the authors reveal that RPA also shields inherited single-stranded DNA in G1, representing replication remnants from the previous cell cycle, to allow for post-mitotic DNA synthesis.