Nature Communications (Jan 2017)
Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells
- Lingyu Meng,
- Cuicui Liu,
- Jinhui Lü,
- Qian Zhao,
- Shengqiong Deng,
- Guangxue Wang,
- Jing Qiao,
- Chuyi Zhang,
- Lixiao Zhen,
- Ying Lu,
- Wenshu Li,
- Yuzhen Zhang,
- Richard G. Pestell,
- Huiming Fan,
- Yi-Han Chen,
- Zhongmin Liu,
- Zuoren Yu
Affiliations
- Lingyu Meng
- Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Cuicui Liu
- Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Jinhui Lü
- Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Qian Zhao
- Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Shengqiong Deng
- Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Guangxue Wang
- Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Jing Qiao
- Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Chuyi Zhang
- Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Lixiao Zhen
- Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Ying Lu
- Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Wenshu Li
- School of Basic Medical Sciences, Wenzhou Medical University
- Yuzhen Zhang
- Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Richard G. Pestell
- Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University
- Huiming Fan
- Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Yi-Han Chen
- Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Zhongmin Liu
- Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Zuoren Yu
- Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- DOI
- https://doi.org/10.1038/ncomms13964
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
MicroRNAs regulate a wide range of biological processes and being able to inhibit their function could allow the development of therapeutic options. Here the authors describe a ‘small RNA zipper’ that sequesters miRNAs by forming a chain of DNA:RNA duplexes.
