mBio
(Apr 2021)
Anaerobic Microbial Metabolism of Dichloroacetate
Gao Chen,
Nannan Jiang,
Manuel I. Villalobos Solis,
Fadime Kara Murdoch,
Robert Waller Murdoch,
Yongchao Xie,
Cynthia M. Swift,
Robert L. Hettich,
Frank E. Löffler
Affiliations
Gao Chen
Center for Environmental Biotechnology, University of Tennessee, Knoxville, Tennessee, USA
Nannan Jiang
ORCiD Center for Environmental Biotechnology, University of Tennessee, Knoxville, Tennessee, USA
Manuel I. Villalobos Solis
Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA
Fadime Kara Murdoch
Center for Environmental Biotechnology, University of Tennessee, Knoxville, Tennessee, USA
Robert Waller Murdoch
Center for Environmental Biotechnology, University of Tennessee, Knoxville, Tennessee, USA
Yongchao Xie
Center for Environmental Biotechnology, University of Tennessee, Knoxville, Tennessee, USA
Cynthia M. Swift
Center for Environmental Biotechnology, University of Tennessee, Knoxville, Tennessee, USA
Robert L. Hettich
ORCiD Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA
Frank E. Löffler
ORCiD Center for Environmental Biotechnology, University of Tennessee, Knoxville, Tennessee, USA
DOI
https://doi.org/10.1128/mBio.00537-21
Journal volume & issue
Vol. 12,
no. 2
Abstract
Read online
Dichloroacetate (DCA) is ubiquitous in the environment due to natural formation via biological and abiotic chlorination processes and the turnover of chlorinated organic materials (e.g., humic substances). Additional sources include DCA usage as a chemical feedstock and cancer drug and its unintentional formation during drinking water disinfection by chlorination.
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