Metabolic dysregulation impairs lymphocyte function during severe SARS-CoV-2 infection

Affiliations

Sanjeev Gurshaney: Cancer Division, Burnett School of Biomedical Science, College of Medicine, University of Central Florida
Anamaria Morales-Alvarez: Cancer Division, Burnett School of Biomedical Science, College of Medicine, University of Central Florida
Kevin Ezhakunnel: Cancer Division, Burnett School of Biomedical Science, College of Medicine, University of Central Florida
Andrew Manalo: Cancer Division, Burnett School of Biomedical Science, College of Medicine, University of Central Florida
Thien-Huong Huynh: Cancer Division, Burnett School of Biomedical Science, College of Medicine, University of Central Florida
Jun-Ichi Abe: Department of Cardiology, The University of Texas MD Anderson Cancer Center
Nhat-Tu Le: Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute
Daniela Weiskopf: Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)
Alessandro Sette: Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)
Daniel S. Lupu: AdventHealth Cancer Institute, AdventHealth Research Institute
Stephen J. Gardell: Translational Research Institute, AdventHealth Research Institute
Hung Nguyen: Cancer Division, Burnett School of Biomedical Science, College of Medicine, University of Central Florida

Abstract

Mitophagy inhibition rescues cellular dysfunction through enhancing metabolic fitness in CD8 and NKT lymphocytes during SARS-CoV-2 infection.