Synthesis and Biological Evaluation of 1,3,8-Triazaspiro[4.5]decane-2,4-dione Derivatives as Myelostimulators

Valentina Yu; Assel Ten; Lyailya Baktybayeva; Indira Sagatbekova; Kaldybay Praliyev; Darya Zolotareva; Tulegen Seilkhanov; Alexey Zazybin

doi:10.1155/2018/7346835

Journal of Chemistry (Jan 2018)

Synthesis and Biological Evaluation of 1,3,8-Triazaspiro[4.5]decane-2,4-dione Derivatives as Myelostimulators

Valentina Yu,
Assel Ten,
Lyailya Baktybayeva,
Indira Sagatbekova,
Kaldybay Praliyev,
Darya Zolotareva,
Tulegen Seilkhanov,
Alexey Zazybin

Affiliations

Valentina Yu: Institute of Chemical Sciences Named after A. B. Bekturov, Walikhanov Str., No. 106, Almaty 050010, Kazakhstan
Assel Ten: Institute of Chemical Sciences Named after A. B. Bekturov, Walikhanov Str., No. 106, Almaty 050010, Kazakhstan
Lyailya Baktybayeva: Al-Farabi Kazakh National University, Al Farabi Av., No. 71, Almaty 050004, Kazakhstan
Indira Sagatbekova: Institute of Chemical Sciences Named after A. B. Bekturov, Walikhanov Str., No. 106, Almaty 050010, Kazakhstan
Kaldybay Praliyev: Institute of Chemical Sciences Named after A. B. Bekturov, Walikhanov Str., No. 106, Almaty 050010, Kazakhstan
Darya Zolotareva: School of Chemical Engineering, Kazakh-British Technical University, 59 Tole-bi Str., Almaty 050000, Kazakhstan
Tulegen Seilkhanov: Laboratory of Engineering Profile NMR Spectroscopy, Sh. Ualikhanov Kokshetau State University, Abay Str., No. 76, Kokshetau 020000, Kazakhstan
Alexey Zazybin: School of Chemical Engineering, Kazakh-British Technical University, 59 Tole-bi Str., Almaty 050000, Kazakhstan

DOI: https://doi.org/10.1155/2018/7346835
Journal volume & issue: Vol. 2018

Abstract

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Spiroconnected N-alkoxyalkylpiperidine hydantoins were obtained via the Strecker reaction of cyanohydrin with ammonium carbonate. 1,3,8-Triazaspiro[4.5]decane-2,4-diones have shown the myelostimulating activity in the artificially induced (with cyclophosphamide) myelodepressive syndrome. The compounds significantly accelerated the regeneration of lymphocyte and granulocyte cell pool of bone marrow hematopoiesis.

Published in Journal of Chemistry

ISSN: 2090-9063 (Print); 2090-9071 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://www.hindawi.com/journals/jchem/

About the journal