The Role of Replication Clamp-Loader Protein HolC of Escherichia coli in Overcoming Replication/Transcription Conflicts

Deani L. Cooper; Taku Harada; Samia Tamazi; Alexander E. Ferrazzoli; Susan T. Lovett

doi:10.1128/mBio.00184-21

mBio (Apr 2021)

The Role of Replication Clamp-Loader Protein HolC of Escherichia coli in Overcoming Replication/Transcription Conflicts

Deani L. Cooper,
Taku Harada,
Samia Tamazi,
Alexander E. Ferrazzoli,
Susan T. Lovett

Affiliations

Deani L. Cooper: Department of Biology, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, USA
Taku Harada: Department of Biology, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, USA
Samia Tamazi: Department of Biology, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, USA
Alexander E. Ferrazzoli: Department of Biology, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, USA
Susan T. Lovett: ORCiD; Department of Biology, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, USA

DOI: https://doi.org/10.1128/mBio.00184-21
Journal volume & issue: Vol. 12, no. 2

Abstract

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Transcription elongation complexes present an impediment to DNA replication. We provide evidence that one component of the replication clamp loader complex, HolC, of Escherichia coli

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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