Nature Communications (Jun 2019)

Efficient base editing for multiple genes and loci in pigs using base editors

  • Jingke Xie,
  • Weikai Ge,
  • Nan Li,
  • Qishuai Liu,
  • Fangbing Chen,
  • Xiaoyu Yang,
  • Xingyun Huang,
  • Zhen Ouyang,
  • Quanjun Zhang,
  • Yu Zhao,
  • Zhaoming Liu,
  • Shixue Gou,
  • Han Wu,
  • Chengdan Lai,
  • Nana Fan,
  • Qin Jin,
  • Hui Shi,
  • Yanhui Liang,
  • Ting Lan,
  • Longquan Quan,
  • Xiaoping Li,
  • Kepin Wang,
  • Liangxue Lai

DOI
https://doi.org/10.1038/s41467-019-10421-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

Read online

Base editors can efficiently produce single nucleotide alterations without requiring a double-strand break. Here the authors show base editing at multiple sites simultaneously in pigs.