WNT: an unexpected tumor suppressor in medulloblastoma

Abstract

Medulloblastoma (MB) represents the most common malignant pediatric brain tumor and is defined by four molecular subgroups with WNT MB having the most favorable prognosis. Our work provides a rational therapeutic option in which the protective effects of WNT-driven MBs may be augmented in Group 3 and 4 MB.

Keywords

• medulloblastoma
• wnt
• beta-catenin
• brain tumor-initiating cell