Recent Advances in the Pharmaceutical and Biomedical Applications of Cyclodextrin-Capped Gold Nanoparticles

Abstract

Ahmed AH Abdellatif,1,2,* Fatma Ahmed,3,* Ahmed M Mohammed,2 Mansour Alsharidah,4 Amal Al-Subaiyel,1 Waad A Samman,5 Aisha A Alhaddad,5 Samiah Hamad Al-Mijalli,6 Mohammed A Amin,1,2 Hassan Barakat,7,8 Shaaban K Osman2,* 1Department of Pharmaceutics, College of Pharmacy, Qassim University, Qassim, 51452, Saudi Arabia; 2Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Assiut, 71524, Egypt; 3Department of Zoology, Faculty of Science, Sohag University, Sohag, 82524, Egypt; 4Department of Physiology, College of Medicine, Qassim University, Buraydah, 51452, Saudi Arabia; 5Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Medina, 42353, Saudi Arabia; 6Department of Biology, College of Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, 11671, Saudi Arabia; 7Department of Food Science and Human Nutrition, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah, 51452, Saudi Arabia; 8Food Technology Department, Faculty of Agriculture, Benha University, Moshtohor, 13736, Egypt*These authors contributed equally to this workCorrespondence: Shaaban K Osman, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Assiut, 71524, Egypt, Tel [phone], Fax [phone], Email [email protected] Ahmed AH Abdellatif, Department of Pharmaceutics, College of Pharmacy, Qassim University, Qassim, 51452, Saudi Arabia, Email [email protected]: The real problem in pharmaceutical preparation is drugs’ poor aqueous solubility, low permeability through biological membranes, and short biological t1/2. Conventional drug delivery systems are not able to overcome these problems. However, cyclodextrins (CDs) and their derivatives can solve these challenges. This article aims to summarize and review the history, properties, and different applications of cyclodextrins, especially the ability of inclusion complex formation. It also refers to the effects of cyclodextrin on drug solubility, bioavailability, and stability. Moreover, it focuses on preparing and applying gold nanoparticles (AuNPs) as novel drug delivery systems. It also studies the uses and effects of cyclodextrins in this field as novel drug carriers and targeting devices. The system formulated from AuNPs linked with CD molecules combines the advantages of both CD and AuNPs. Cyclodextrins benefit in increasing aqueous drug solubility, loading capacity, stability, and size control of gold NPs. Also, AuNPs are applied as diagnostic and therapeutic agents because of their unique chemical properties. Plus, AuNPs possess several advantages such as ease of detection, targeted and selective drug delivery, greater surface area, high loading efficiency, and higher stability than microparticles. In the present article, we tried to present the potential pharmaceutical applications of CD-derived AuNPs in biomedical applications including antibacterial, anticancer, gene-drug delivery, and various targeted drug delivery applications. Also, the article highlighted the role of CDs in the preparation and improvement of catalytic enzymes, the formation of self-assembling molecular print boards, the fabrication of supramolecular functionalized electrodes, and biosensors formation.Keywords: AuNPs, nanotechnology, drug delivery, drug targeting, inclusion complexes, cancer management

Keywords

• aunps
• nanotechnology
• drug delivery
• drug targeting
• inclusion complexes
• cancer management