Diversity-Orientated Synthesis and Biological Properties of Compounds Based on the <i>N</i>-Phenylquinoneimine Scaffold

Abstract

The N-phenylquinoneimine scaffold is a versatile synthetic platform that has gained significant attention in the field of drug discovery due to its structural diversity and capacity to interact with biologically relevant targets. This review explores established synthetic methodologies and highlights the significant biological activities exhibited by compounds derived from this scaffold, their implications for medicinal chemistry, and the development of novel therapeutics.

Keywords

• <i>N</i>-phenylquinoneimine
• diversity-orientated synthesis
• biological activity
• DNA
• reactive metabolites
• drugs