Deep Eutectic Solvents as Active Pharmaceutical Ingredient Delivery Systems in the Treatment of Metabolic Related Diseases

Cixin Huang; Cixin Huang; Cixin Huang; Xiunian Chen; Xiunian Chen; Xiunian Chen; Chao Wei; Chao Wei; Hongwei Wang; Hongwei Wang; Hua Gao; Hua Gao; Hua Gao

doi:10.3389/fphar.2021.794939

Frontiers in Pharmacology (Dec 2021)

Deep Eutectic Solvents as Active Pharmaceutical Ingredient Delivery Systems in the Treatment of Metabolic Related Diseases

Cixin Huang,
Cixin Huang,
Cixin Huang,
Xiunian Chen,
Xiunian Chen,
Xiunian Chen,
Chao Wei,
Chao Wei,
Hongwei Wang,
Hongwei Wang,
Hua Gao,
Hua Gao,
Hua Gao

Affiliations

Cixin Huang: State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao, China
Cixin Huang: Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan, China
Cixin Huang: Medical College, Qingdao University, Qingdao, China
Xiunian Chen: State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao, China
Xiunian Chen: Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan, China
Xiunian Chen: Medical College, Qingdao University, Qingdao, China
Chao Wei: State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao, China
Chao Wei: School of Ophthalmology, Shandong First Medical University, Jinan, China
Hongwei Wang: State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao, China
Hongwei Wang: School of Ophthalmology, Shandong First Medical University, Jinan, China
Hua Gao: State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao, China
Hua Gao: Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan, China
Hua Gao: School of Ophthalmology, Shandong First Medical University, Jinan, China

DOI: https://doi.org/10.3389/fphar.2021.794939
Journal volume & issue: Vol. 12

Abstract

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Metabolic related diseases such as cancer, diabetes mellitus and atherosclerosis are major challenges for human health and safety worldwide due to their associations with high morbidity and mortality. It is of great significance to develop the effective active pharmaceutical ingredient (API) delivery systems for treatment of metabolic diseases. With their unique merits like easy preparation, high adjustability, low toxicity, low cost, satisfactory stability and biodegradation, deep eutectic solvents (DESs) are unarguably green and sustainable API delivery systems that have been developed to improve drug solubility and treat metabolic related diseases including cancer, diabetes mellitus and atherosclerosis. Many reports about DESs as API delivery systems in the therapy of cancer, diabetes mellitus and atherosclerosis exist but no systematic overview of these results is available, which motivated the current work.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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