An epidemic Zika virus isolate suppresses antiviral immunity by disrupting antigen presentation pathways

Ryan D. Pardy; Stefanie F. Valbon; Brendan Cordeiro; Connie M. Krawczyk; Martin J. Richer

doi:10.1038/s41467-021-24340-0

Nature Communications (Jun 2021)

An epidemic Zika virus isolate suppresses antiviral immunity by disrupting antigen presentation pathways

Ryan D. Pardy,
Stefanie F. Valbon,
Brendan Cordeiro,
Connie M. Krawczyk,
Martin J. Richer

Affiliations

Ryan D. Pardy: Department of Microbiology & Immunology, McGill University
Stefanie F. Valbon: Department of Microbiology & Immunology, McGill University
Brendan Cordeiro: Department of Microbiology & Immunology, McGill University
Connie M. Krawczyk: Department of Metabolism and Nutritional Programming, Van Andel Research Institute
Martin J. Richer: Department of Microbiology & Immunology, McGill University

DOI: https://doi.org/10.1038/s41467-021-24340-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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The CD8 T cell response to Zika virus is known to be a critical component of the host immune response to infection. Here the authors show a Zika virus isolate specific disruption of antigen processing that impacts the host response and impairs viral clearance providing evidence of isolate specific impacts on the immune response to infection

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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