Pathogenetic substantiation and experience of using serotonin adipate in complex therapy of functional bowel obstruction in surgical practice

Abstract

Despite considerable achievements in surgical treatment methods and management of patients during the postoperative period, functional bowel obstruction (FBO) is a common complication of abdominal surgery. According to some authors, the prevalence of this complication may be as high as 25% of all postoperative complications. Currently, there is no generally accepted unified scheme for treatment of postoperative FBO. In this regard, the use of pathogenetically substantiated methods with proven efficacy and safety of use in clinical practice for treatment of this condition is relevant in terms of scientific and practical significance. It is believed that the gastrointestinal smooth muscle contractile function impairment due to impaired interaction between serotonin and serotonin receptors plays an important role in FBO. This is a concept of serotonin deficiency. According to the concept, smooth muscle dysfunction in the gastrointestinal tract and blood vessels that occurs in patients during the postoperative period is associated with absolute or relative serotonin deficiency. This review reports pathogenetic substantiation and experience of using serotonin adipate in the complex therapy of FBO in surgical patients during the postoperative period based on the assessment of available information. The analysis of clinical trials and observations pesented in the review shows that the use of serotonin adipate starting from the first hour of postoperative period can significantly improve the outcome and quality of treatment provided to patients with postoperative FBO, since it is a pathogenetically substantiated component of complex therapy of this condition.

Keywords

• serotonin
• functional bowel obstruction
• smooth muscle dysfunction
• postoperative complications
• gastrointestinal trac