Association of Different ABO and Rh Blood Groups with the Erythroprotective Effect of Extracts from <i>Navicula incerta</i> and Their Anti-Inflammatory and Antiproliferative Properties
Saúl Ruiz-Cruz,
Ricardo Iván González-Vega,
Ramón Enrique Robles-Zepeda,
Aline Reyes-Díaz,
José Antonio López-Elías,
Maritza Lizeth Álvarez-Ainza,
Francisco Javier Cinco-Moroyoqui,
Ramón Alfonso Moreno-Corral,
Francisco Javier Wong-Corral,
Jesús Borboa-Flores,
Yaeel Isbeth Cornejo-Ramírez,
Carmen Lizette Del-Toro-Sánchez
Affiliations
Saúl Ruiz-Cruz
Department of Research and Postgraduate in Food, University of Sonora, Blvd Luis Encinas y Rosales S/N, Col. Centro, Hermosillo 83000, Mexico
Ricardo Iván González-Vega
Department of Medical and Life Sciences, Cienega University Center (CUCIÉNEGA), University of Guadalajara, Av. Universidad 1115, Lindavista, Ocotlán 47820, Mexico
Ramón Enrique Robles-Zepeda
Department of Research and Postgraduate in Food, University of Sonora, Blvd Luis Encinas y Rosales S/N, Col. Centro, Hermosillo 83000, Mexico
Aline Reyes-Díaz
Nursing Department, State University of Sonora, Av. Niños Héroes, San Javier, Magdalena de Kino 84160, Mexico
José Antonio López-Elías
Department of Research and Postgraduate in Food, University of Sonora, Blvd Luis Encinas y Rosales S/N, Col. Centro, Hermosillo 83000, Mexico
Maritza Lizeth Álvarez-Ainza
Department of Research and Postgraduate in Food, University of Sonora, Blvd Luis Encinas y Rosales S/N, Col. Centro, Hermosillo 83000, Mexico
Francisco Javier Cinco-Moroyoqui
Department of Research and Postgraduate in Food, University of Sonora, Blvd Luis Encinas y Rosales S/N, Col. Centro, Hermosillo 83000, Mexico
Ramón Alfonso Moreno-Corral
Department of Research and Postgraduate in Food, University of Sonora, Blvd Luis Encinas y Rosales S/N, Col. Centro, Hermosillo 83000, Mexico
Francisco Javier Wong-Corral
Department of Research and Postgraduate in Food, University of Sonora, Blvd Luis Encinas y Rosales S/N, Col. Centro, Hermosillo 83000, Mexico
Jesús Borboa-Flores
Department of Research and Postgraduate in Food, University of Sonora, Blvd Luis Encinas y Rosales S/N, Col. Centro, Hermosillo 83000, Mexico
Yaeel Isbeth Cornejo-Ramírez
Department of Research and Postgraduate in Food, University of Sonora, Blvd Luis Encinas y Rosales S/N, Col. Centro, Hermosillo 83000, Mexico
Carmen Lizette Del-Toro-Sánchez
Department of Research and Postgraduate in Food, University of Sonora, Blvd Luis Encinas y Rosales S/N, Col. Centro, Hermosillo 83000, Mexico
Previous studies have reported that different blood groups are associated with the risk of chronic degenerative diseases that mainly involve inflammation and neoplastic processes. We investigate the relationship between blood groups and the erythroprotective effect of extracts from Navicula incerta against oxidative damage as a proposal to develop drugs designed for people with a specific blood type related to chronic pathology. The study was carried out through the elucidation of the erythroprotective potential, anti-inflammatory and antiproliferative activity of Navicula incerta. Research suggests that the presence or absence of certain blood groups increases or decreases the abilities of certain phytochemicals to inhibit oxidative stress, which is related to the systemic inflammatory response involved in the development of different types of cancer. The pigment-rich extracts from Navicula incerta inhibit ROO•- induced oxidative stress in human erythrocytes on the A RhD+ve antigen without compromising the structure of the cell membrane. This result is very important, since the A antigen is related to the susceptibility of contracting prostate cancer. Similarly, it was possible to inhibit the proliferation of cervical (HeLa) and prostate (PC-3) carcinoma. The combinatorial analysis of different biological activities can help design phytochemicals as new candidates for preventive drugs treating the chronic degenerative diseases associated with a specific blood group.
