Nature Communications (Mar 2019)
Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR
Abstract
IRE1 and PERK, both important mediators of the unfold protein response pathway, are differentially regulated during plasma cell differentiation. Here the authors show that an ufmylation target, Ufbp1, suppresses PERK to stimulate plasma cell development and is induced by the IRE1/XBP1 pathway to promote ER expansion .