Nature Communications (Nov 2021)
Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity
- Irene A. Abela,
- Chloé Pasin,
- Magdalena Schwarzmüller,
- Selina Epp,
- Michèle E. Sickmann,
- Merle M. Schanz,
- Peter Rusert,
- Jacqueline Weber,
- Stefan Schmutz,
- Annette Audigé,
- Liridona Maliqi,
- Annika Hunziker,
- Maria C. Hesselman,
- Cyrille R. Niklaus,
- Jochen Gottschalk,
- Eméry Schindler,
- Alexander Wepf,
- Urs Karrer,
- Aline Wolfensberger,
- Silvana K. Rampini,
- Patrick M. Meyer Sauteur,
- Christoph Berger,
- Michael Huber,
- Jürg Böni,
- Dominique L. Braun,
- Maddalena Marconato,
- Markus G. Manz,
- Beat M. Frey,
- Huldrych F. Günthard,
- Roger D. Kouyos,
- Alexandra Trkola
Affiliations
- Irene A. Abela
- Institute of Medical Virology, University of Zurich
- Chloé Pasin
- Institute of Medical Virology, University of Zurich
- Magdalena Schwarzmüller
- Institute of Medical Virology, University of Zurich
- Selina Epp
- Institute of Medical Virology, University of Zurich
- Michèle E. Sickmann
- Institute of Medical Virology, University of Zurich
- Merle M. Schanz
- Institute of Medical Virology, University of Zurich
- Peter Rusert
- Institute of Medical Virology, University of Zurich
- Jacqueline Weber
- Institute of Medical Virology, University of Zurich
- Stefan Schmutz
- Institute of Medical Virology, University of Zurich
- Annette Audigé
- Institute of Medical Virology, University of Zurich
- Liridona Maliqi
- Institute of Medical Virology, University of Zurich
- Annika Hunziker
- Institute of Medical Virology, University of Zurich
- Maria C. Hesselman
- Institute of Medical Virology, University of Zurich
- Cyrille R. Niklaus
- Institute of Medical Virology, University of Zurich
- Jochen Gottschalk
- Blood Transfusion Service Zurich
- Eméry Schindler
- Blood Transfusion Service Zurich
- Alexander Wepf
- Institute of Laboratory Medicine, Cantonal Hospital Winterthur
- Urs Karrer
- Department of Medicine, Cantonal Hospital Winterthur
- Aline Wolfensberger
- Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
- Silvana K. Rampini
- Department of Internal Medicine, University Hospital Zurich
- Patrick M. Meyer Sauteur
- Division of Infectious Diseases and Hospital Epidemiology, University Children’s Hospital Zurich
- Christoph Berger
- Division of Infectious Diseases and Hospital Epidemiology, University Children’s Hospital Zurich
- Michael Huber
- Institute of Medical Virology, University of Zurich
- Jürg Böni
- Institute of Medical Virology, University of Zurich
- Dominique L. Braun
- Institute of Medical Virology, University of Zurich
- Maddalena Marconato
- Department of Medical Oncology and Hematology, University Hospital and University of Zurich
- Markus G. Manz
- Department of Medical Oncology and Hematology, University Hospital and University of Zurich
- Beat M. Frey
- Blood Transfusion Service Zurich
- Huldrych F. Günthard
- Institute of Medical Virology, University of Zurich
- Roger D. Kouyos
- Institute of Medical Virology, University of Zurich
- Alexandra Trkola
- Institute of Medical Virology, University of Zurich
- DOI
- https://doi.org/10.1038/s41467-021-27040-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
How the immune responses induced by SARS-CoV-2 and human coronavirus (hCoV) crosstalk is still unclear. Here the authors profile the humoral responses of prepandemic and SARS-CoV-2-infected donors to find that higher hCoV antibody titers are associated with SARS-CoV-2 negativity, and with reduced hospitalization in SARS-CoV-2 positive patients.
