Nature Communications (Apr 2016)
Genetic and environmental influences interact with age and sex in shaping the human methylome
- Jenny van Dongen,
- Michel G. Nivard,
- Gonneke Willemsen,
- Jouke-Jan Hottenga,
- Quinta Helmer,
- Conor V. Dolan,
- Erik A. Ehli,
- Gareth E. Davies,
- Maarten van Iterson,
- Charles E. Breeze,
- Stephan Beck,
- BIOS Consortium,
- H. Eka Suchiman,
- Rick Jansen,
- Joyce B. van Meurs,
- Bastiaan T. Heijmans,
- P. Eline Slagboom,
- Dorret I. Boomsma
Affiliations
- Jenny van Dongen
- Department of Biological Psychology, VU Amsterdam
- Michel G. Nivard
- Department of Biological Psychology, VU Amsterdam
- Gonneke Willemsen
- Department of Biological Psychology, VU Amsterdam
- Jouke-Jan Hottenga
- Department of Biological Psychology, VU Amsterdam
- Quinta Helmer
- Department of Biological Psychology, VU Amsterdam
- Conor V. Dolan
- Department of Biological Psychology, VU Amsterdam
- Erik A. Ehli
- Avera Institute for Human Genetics
- Gareth E. Davies
- Avera Institute for Human Genetics
- Maarten van Iterson
- Department of Molecular Epidemiology, Leiden University Medical Center
- Charles E. Breeze
- UCL Cancer Institute, University College London
- Stephan Beck
- UCL Cancer Institute, University College London
- BIOS Consortium
- H. Eka Suchiman
- Department of Molecular Epidemiology, Leiden University Medical Center
- Rick Jansen
- Department of Psychiatry, VU University Medical Center
- Joyce B. van Meurs
- Department of Internal Medicine, Erasmus Medical Center
- Bastiaan T. Heijmans
- Department of Molecular Epidemiology, Leiden University Medical Center
- P. Eline Slagboom
- Department of Molecular Epidemiology, Leiden University Medical Center
- Dorret I. Boomsma
- Department of Biological Psychology, VU Amsterdam
- DOI
- https://doi.org/10.1038/ncomms11115
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
Differential impact of genetic and environmental influences on DNA methylation may result in sex- and age-related physiological variation and disease susceptibility. By analysing DNA methylome of 2,603 individuals from twin families, here, the authors establish a catalogue of between-individual variation in DNA methylation.
