Communications Biology (Apr 2022)
Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit
- Nicholas K. Hurlburt,
- Leah J. Homad,
- Irika Sinha,
- Madeleine F. Jennewein,
- Anna J. MacCamy,
- Yu-Hsin Wan,
- Jim Boonyaratanakornkit,
- Anton M. Sholukh,
- Abigail M. Jackson,
- Panpan Zhou,
- Dennis R. Burton,
- Raiees Andrabi,
- Gabriel Ozorowski,
- Andrew B. Ward,
- Leonidas Stamatatos,
- Marie Pancera,
- Andrew T. McGuire
Affiliations
- Nicholas K. Hurlburt
- Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division
- Leah J. Homad
- Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division
- Irika Sinha
- Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division
- Madeleine F. Jennewein
- Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division
- Anna J. MacCamy
- Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division
- Yu-Hsin Wan
- Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division
- Jim Boonyaratanakornkit
- Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division
- Anton M. Sholukh
- Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division
- Abigail M. Jackson
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Panpan Zhou
- Department of Immunology and Microbiology, The Scripps Research Institute
- Dennis R. Burton
- Department of Immunology and Microbiology, The Scripps Research Institute
- Raiees Andrabi
- Department of Immunology and Microbiology, The Scripps Research Institute
- Gabriel Ozorowski
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Andrew B. Ward
- Department of Integrative Structural and Computational Biology, The Scripps Research Institute
- Leonidas Stamatatos
- Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division
- Marie Pancera
- Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division
- Andrew T. McGuire
- Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division
- DOI
- https://doi.org/10.1038/s42003-022-03262-7
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
Structural and functional characterisation of an antibody CV3-25 reveals wide neutralisation spectrum of the antibody against multiple SARS-CoV2 variants.
