肠道菌群与卒中后肺炎相关性的研究进展 Advances in the Correlation between Gut Microbiota and Post-stroke Pneumonia

Abstract

近年来，肠道菌群被认为与卒中后肺炎有关，肠道菌群及其代谢产物通过神经-免疫影响卒中后肺炎，靶向调节肠道菌群如粪菌移植、补充益生菌/益生元有望成为控制卒中后肺炎的重要手段。本文从肠道菌群对卒中后肺炎的影响、可能作用机制及肠道菌群调节在卒中后肺炎治疗中的应用效果等方面进行综述，阐述了卒中后感染的一个易被忽视的重要传染源，以期促进卒中后肺炎靶向治疗策略的发展。 Abstract: In recent years, gut microbiota is considered to be related to post-stroke pneumonia. gut microbiota and its metabolites affect post-stroke pneumonia through neuroimmunity. Targeted regulation of gut microbiota, such as fecal bacteria transplantation, and supplementation of probiotics/prebiotics are expected to become important means to control post-stroke pneumonia. This paper reviewed the influence of gut microbiota on post-stroke pneumonia, and its possible mechanism, as well as the effect of gut microbiota regulation in the treatment of post-stroke pneumonia, described an important neglected infectious source of post-stroke infection, in order to promote the development of targeted therapy strategies for post-stroke pneumonia.

Keywords

• 卒中后肺炎
• 肠道菌群
• 肠道菌群失调
• 肠道功能障碍
• post-stroke pneumonia
• gut microbiota
• intestinal flora dysregulation
• gut dysfunction