Intensive Care Medicine Experimental (Mar 2021)
National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research
- Asher A. Mendelson,
- Casey Lansdell,
- Alison E. Fox-Robichaud,
- Patricia Liaw,
- Jaskirat Arora,
- Jean-François Cailhier,
- Gediminas Cepinskas,
- Emmanuel Charbonney,
- Claudia dos Santos,
- Dhruva Dwivedi,
- Christopher G. Ellis,
- Dean Fergusson,
- Kirsten Fiest,
- Sean E. Gill,
- Kathryn Hendrick,
- Victoria T. Hunniford,
- Paulina M. Kowalewska,
- Karla Krewulak,
- Christian Lehmann,
- Kimberly Macala,
- John C. Marshall,
- Laura Mawdsley,
- Braedon McDonald,
- Ellen McDonald,
- Sarah K. Medeiros,
- Valdirene S. Muniz,
- Marcin Osuchowski,
- Justin Presseau,
- Neha Sharma,
- Sahar Sohrabipour,
- Janet Sunohara-Neilson,
- Gloria Vázquez-Grande,
- Ruud A. W. Veldhuizen,
- Donald Welsh,
- Brent W. Winston,
- Ryan Zarychanski,
- Haibo Zhang,
- Juan Zhou,
- Manoj M. Lalu,
- Sepsis Canada’s National Preclinical Sepsis Platform
Affiliations
- Asher A. Mendelson
- Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario
- Casey Lansdell
- Regenerative Medicine Program, Ottawa Hospital Research Institute
- Alison E. Fox-Robichaud
- Department of Medicine, McMaster University
- Patricia Liaw
- Department of Medicine, McMaster University
- Jaskirat Arora
- Thrombosis and Atherosclerosis Research Institute
- Jean-François Cailhier
- Centre de Recherche du Centre Hospitalier de l’Université de Montréal
- Gediminas Cepinskas
- Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario
- Emmanuel Charbonney
- Centre de Recherche du Centre Hospitalier de l’Université de Montréal
- Claudia dos Santos
- Keenan Research Centre for Biomedical Science, Unity Health Toronto
- Dhruva Dwivedi
- Department of Medicine, McMaster University
- Christopher G. Ellis
- Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario
- Dean Fergusson
- Clinical Epidemiology Program, Ottawa Hospital Research Institute
- Kirsten Fiest
- Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary
- Sean E. Gill
- Centre for Critical Illness Research, Lawson Health Research Institute
- Kathryn Hendrick
- Department of Communications, Global Sepsis Alliance, Canada Sector
- Victoria T. Hunniford
- Clinical Epidemiology Program, Ottawa Hospital Research Institute
- Paulina M. Kowalewska
- Robarts Research Institute, University of Western Ontario
- Karla Krewulak
- Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary
- Christian Lehmann
- Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University
- Kimberly Macala
- Department of Critical Care Medicine, Royal Alexandra Hospital, University of Alberta
- John C. Marshall
- Keenan Research Centre for Biomedical Science, Unity Health Toronto
- Laura Mawdsley
- Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario
- Braedon McDonald
- Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary
- Ellen McDonald
- Department of Medicine, McMaster University
- Sarah K. Medeiros
- Thrombosis and Atherosclerosis Research Institute
- Valdirene S. Muniz
- Department of Medicine, McMaster University
- Marcin Osuchowski
- Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
- Justin Presseau
- Clinical Epidemiology Program, Ottawa Hospital Research Institute
- Neha Sharma
- Thrombosis and Atherosclerosis Research Institute
- Sahar Sohrabipour
- Thrombosis and Atherosclerosis Research Institute
- Janet Sunohara-Neilson
- Animal Resources Centre, University Health Network
- Gloria Vázquez-Grande
- Department of Internal Medicine, Section of Critical Care, University of Manitoba
- Ruud A. W. Veldhuizen
- Centre for Critical Illness Research, Lawson Health Research Institute
- Donald Welsh
- Robarts Research Institute, University of Western Ontario
- Brent W. Winston
- Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary
- Ryan Zarychanski
- Department of Internal Medicine, Section of Critical Care, University of Manitoba
- Haibo Zhang
- Keenan Research Centre for Biomedical Science, Unity Health Toronto
- Juan Zhou
- Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University
- Manoj M. Lalu
- Clinical Epidemiology Program, Ottawa Hospital Research Institute
- Sepsis Canada’s National Preclinical Sepsis Platform
- DOI
- https://doi.org/10.1186/s40635-020-00366-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 19
Abstract
Abstract Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into routine clinical practice. Factors that contribute to this crisis of translation include poor representation by preclinical models of the complex human condition of sepsis, bias in preclinical studies, as well as limitations of single-laboratory methodology. To overcome some of these shortcomings, multicentre preclinical studies—defined as a research experiment conducted in two or more research laboratories with a common protocol and analysis—are expected to maximize transparency, improve reproducibility, and enhance generalizability. The ultimate objective is to increase the efficiency and efficacy of bench-to-bedside translation for preclinical sepsis research and improve outcomes for patients with life-threatening infection. To this end, we organized the first meeting of the National Preclinical Sepsis Platform (NPSP). This multicentre preclinical research collaboration of Canadian sepsis researchers and stakeholders was established to study the pathophysiology of sepsis and accelerate movement of promising therapeutics into early phase clinical trials. Integrated knowledge translation and shared decision-making were emphasized to ensure the goals of the platform align with clinical researchers and patient partners. 29 participants from 10 independent labs attended and discussed four main topics: (1) objectives of the platform; (2) animal models of sepsis; (3) multicentre methodology and (4) outcomes for evaluation. A PIRO model (predisposition, insult, response, organ dysfunction) for experimental design was proposed to strengthen linkages with interdisciplinary researchers and key stakeholders. This platform represents an important resource for maximizing translational impact of preclinical sepsis research.
Keywords
- Sepsis
- Experimental models of sepsis
- Multicentre preclinical
- Translation
- Reproducibility
- Multi-stakeholder
