Frontiers in Neurology (Dec 2020)

Impact of Cryotherapy on Sensory, Motor, and Autonomic Neuropathy in Breast Cancer Patients Receiving Paclitaxel: A Randomized, Controlled Trial

  • Ding Quan Ng,
  • Ding Quan Ng,
  • Chia Jie Tan,
  • Boon Chua Soh,
  • Mabel May Leng Tan,
  • Soon Yue Loh,
  • Yam Eng Tan,
  • Hui Hui Ong,
  • Peggy Pei Chee Teng,
  • Jack Junjie Chan,
  • Wen Yee Chay,
  • Joycelyn Lee,
  • Gillianne Lai,
  • Sok Yuen Beh,
  • Tira Jing Ying Tan,
  • Yoon Sim Yap,
  • Guek Eng Lee,
  • Mabel Wong,
  • Rebecca Dent,
  • Rebecca Dent,
  • Yew Long Lo,
  • Yew Long Lo,
  • Yew Long Lo,
  • Alexandre Chan,
  • Alexandre Chan,
  • Alexandre Chan,
  • Kiley Wei-Jen Loh,
  • Kiley Wei-Jen Loh

DOI
https://doi.org/10.3389/fneur.2020.604688
Journal volume & issue
Vol. 11

Abstract

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Introduction: We conducted a randomized controlled trial evaluating the efficacy and tolerability of cryotherapy in preventing chemotherapy-induced peripheral neuropathy (CIPN) in patients with early breast cancer receiving neo/adjuvant weekly paclitaxel.Methods: Patients were recruited from the National Cancer Centre Singapore and randomized (1:1) to receive either cryotherapy or usual care. Cryotherapy was applied as frozen gloves and socks on all extremities from 15 min before paclitaxel until 15 min post-infusion every cycle. Efficacy was measured by patient-reported outcomes (Patient Neurotoxicity Questionnaire [PNQ] and EORTC QLQ-CIPN20) and electrophysiological assessments. The primary endpoint was PNQ severity at 2 weeks after 12 cycles of weekly paclitaxel.Results: A total of 46 patients were recruited, of which 8 dropped out before paclitaxel treatment, leaving 38 evaluable. There was no significant difference in PNQ severity between cryotherapy and usual care at 2 weeks after paclitaxel treatment (sensory: p = 0.721; motor: p = 1.000). A benefit was observed at 3 months post-paclitaxel based on PNQ (sensory: 14.3 vs. 41.2%, p = 0.078; motor: 0 vs. 29.4%, p = 0.012) and CIPN20 (sensory: β = −3.6, 95%CI = −10.5–3.4, p = 0.308; motor: β = −7.3, 95%CI = −14.6–0, p = 0.051). Additionally, cryotherapy subjects have lower CIPN20 autonomic score (β = −5.84, 95%CI = −11.15 to −0.524, p = 0.031) and higher sympathetic skin response hand amplitudes (β = 0.544, 95%CI = 0.108–0.98, p = 0.014), suggesting possible autonomic benefits from cryotherapy. Temporary interruption with cryotherapy occurred in 80.9% of the subjects due to cold intolerance.Conclusions: There is insufficient evidence that cryotherapy prevents sensory neuropathy which may be due to the high rates of cryotherapy interruption in this study. The autonomic benefits of cryotherapy should be further investigated with appropriate outcome measures.Clinical Trial Registration:ClinicalTrials.gov: NCT03429972.

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