Microorganisms (Sep 2022)

Epidemiological and Serological Analysis of a SARS-CoV-2 Outbreak in a Nursing Home: Impact of SARS-CoV-2 Vaccination and Enhanced Neutralizing Immunity Following Breakthrough Infection

  • Barbara I. Streibl,
  • Heidi Lahne,
  • Andreas Grahl,
  • Philipp Agsten,
  • Magdalena Bichler,
  • Christa Büchl,
  • Marco Damzog,
  • Ute Eberle,
  • Stefan Gärtner,
  • Bernhard Hobmaier,
  • Gabriele Margos,
  • Martin Hoch,
  • Sabrina Jungnick,
  • Walter Jonas,
  • Katharina Katz,
  • Liane Laubert,
  • Barbara Schutt,
  • Cornelia Seidl,
  • Bianca Treis,
  • Daniel Weindl,
  • Karen Zilch,
  • Manfred Wildner,
  • Bernhard Liebl,
  • Nikolaus Ackermann,
  • Andreas Sing,
  • Volker Fingerle

DOI
https://doi.org/10.3390/microorganisms10091809
Journal volume & issue
Vol. 10, no. 9
p. 1809

Abstract

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Background: Despite a vaccination rate of 82.0% (n = 123/150), a SARS-CoV-2 (Alpha) outbreak with 64.7% (n = 97/150) confirmed infections occurred in a nursing home in Bavaria, Germany. Objective: the aim of this retrospective cohort study was to examine the effects of the Corminaty vaccine in a real-life outbreak situation and to obtain insights into the antibody response to both vaccination and breakthrough infection. Methods: the antibody status of 106 fully vaccinated individuals (54/106 breakthrough infections) and epidemiological data on all 150 residents and facility staff were evaluated. Results: SARS-CoV-2 infections (positive RT-qPCR) were detected in 56.9% (n = 70/123) of fully vaccinated, compared to 100% (n = 27/27) of incompletely or non-vaccinated individuals. The proportion of hospitalized and deceased was 4.1% (n = 5/123) among fully vaccinated and therewith lower compared to 18.5% (n = 5/27) hospitalized and 11.1% (n = 3/27) deceased among incompletely or non-vaccinated. Ct values were significantly lower in incompletely or non-vaccinated (p = 0.02). Neutralizing antibodies were detected in 99.1% (n = 105/106) of serum samples with significantly higher values (p α-N-antibodies were detected in 37.7% of PCR positive but not in PCR negative individuals. Conclusion: Altogether, our data indicate that SARS-CoV-2 vaccination does provide protection against infection, severe disease progression and death with regards to the Alpha variant. Nonetheless, it also shows that infection and transmission are possible despite full vaccination. It further indicates that breakthrough infections can significantly enhance α-S- and neutralizing antibody responses, indicating a possible benefit from booster vaccinations.

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