Blue Light and Temperature Actigraphy Measures Predicting Metabolic Health Are Linked to Melatonin Receptor Polymorphism
Denis Gubin,
Konstantin Danilenko,
Oliver Stefani,
Sergey Kolomeichuk,
Alexander Markov,
Ivan Petrov,
Kirill Voronin,
Marina Mezhakova,
Mikhail Borisenkov,
Aislu Shigabaeva,
Natalya Yuzhakova,
Svetlana Lobkina,
Dietmar Weinert,
Germaine Cornelissen
Affiliations
Denis Gubin
Department of Biology, Tyumen Medical University, 625023 Tyumen, Russia
Konstantin Danilenko
Laboratory for Chronobiology and Chronomedicine, Research Institute of Biomedicine and Biomedical Technologies, Tyumen Medical University, 625023 Tyumen, Russia
Oliver Stefani
Department Engineering and Architecture, Institute of Building Technology and Energy, Lucerne University of Applied Sciences and Arts, 6048 Horw, Switzerland
Sergey Kolomeichuk
Laboratory for Genomics, Proteomics, and Metabolomics, Research Institute of Biomedicine and Biomedical Technologies, Medical University, 625023 Tyumen, Russia
Alexander Markov
Laboratory for Genomics, Proteomics, and Metabolomics, Research Institute of Biomedicine and Biomedical Technologies, Medical University, 625023 Tyumen, Russia
Ivan Petrov
Department of Biological & Medical Physics UNESCO, Medical University, 625023 Tyumen, Russia
Kirill Voronin
Laboratory for Genomics, Proteomics, and Metabolomics, Research Institute of Biomedicine and Biomedical Technologies, Medical University, 625023 Tyumen, Russia
Marina Mezhakova
Laboratory for Genomics, Proteomics, and Metabolomics, Research Institute of Biomedicine and Biomedical Technologies, Medical University, 625023 Tyumen, Russia
Mikhail Borisenkov
Department of Molecular Immunology and Biotechnology, Institute of Physiology of the Federal Research Centre Komi Science Centre, Ural Branch of the Russian Academy of Sciences, 167982 Syktyvkar, Russia
Aislu Shigabaeva
Laboratory for Chronobiology and Chronomedicine, Research Institute of Biomedicine and Biomedical Technologies, Tyumen Medical University, 625023 Tyumen, Russia
Natalya Yuzhakova
Laboratory for Genomics, Proteomics, and Metabolomics, Research Institute of Biomedicine and Biomedical Technologies, Medical University, 625023 Tyumen, Russia
Svetlana Lobkina
Healthcare Institution of Yamalo-Nenets Autonomous Okrug “Tarko-Sale Central District Hospital”, 629850 Urengoy, Russia
Dietmar Weinert
Institute of Biology/Zoology, Martin Luther University, 06108 Halle-Wittenberg, Germany
Germaine Cornelissen
Department of Integrated Biology and Physiology, University of Minnesota, Minneapolis, MN 55455, USA
This study explores the relationship between the light features of the Arctic spring equinox and circadian rhythms, sleep and metabolic health. Residents (N = 62) provided week-long actigraphy measures, including light exposure, which were related to body mass index (BMI), leptin and cortisol. Lower wrist temperature (wT) and higher evening blue light exposure (BLE), expressed as a novel index, the nocturnal excess index (NEIbl), were the most sensitive actigraphy measures associated with BMI. A higher BMI was linked to nocturnal BLE within distinct time windows. These associations were present specifically in carriers of the MTNR1B rs10830963 G-allele. A larger wake-after-sleep onset (WASO), smaller 24 h amplitude and earlier phase of the activity rhythm were associated with higher leptin. Higher cortisol was associated with an earlier M10 onset of BLE and with our other novel index, the Daylight Deficit Index of blue light, DDIbl. We also found sex-, age- and population-dependent differences in the parametric and non-parametric indices of BLE, wT and physical activity, while there were no differences in any sleep characteristics. Overall, this study determined sensitive actigraphy markers of light exposure and wT predictive of metabolic health and showed that these markers are linked to melatonin receptor polymorphism.
