Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells

Holly Rore; Nicholas Owen; Raul Eduardo Piña-Aguilar; Kevin Docherty; Ryohei Sekido

doi:10.1038/s42003-021-02322-8

Communications Biology (Jun 2021)

Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells

Holly Rore,
Nicholas Owen,
Raul Eduardo Piña-Aguilar,
Kevin Docherty,
Ryohei Sekido

Affiliations

Holly Rore: Institute of Medical Sciences, Foresterhill, University of Aberdeen
Nicholas Owen: Institute of Ophthalmology, University College London
Raul Eduardo Piña-Aguilar: Institute of Medical Sciences, Foresterhill, University of Aberdeen
Kevin Docherty: Institute of Medical Sciences, Foresterhill, University of Aberdeen
Ryohei Sekido: Institute of Medical Sciences, Foresterhill, University of Aberdeen

DOI: https://doi.org/10.1038/s42003-021-02322-8
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 12

Abstract

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Rore et al generate testicular somatic cell-like cells (TesLCs) including Sertoli cell-like cells from mouse embryonic stem cells in xeno-free culture. They created testicular organoids in aggregation co-culture of TesLCs and epiblast-like cells (EpiLCs) and also find that TesLC-conditioned media promotes the differentiation of EpiLCs into primordial germ-like cells (PGCLCs).

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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