OncoTargets and Therapy (Feb 2020)
Upregulation of Cullin 4B Promotes Gastric Cancer and Predicts Poor Prognosis
Abstract
Ping Wu,1 Haolin Hu,2 Jinwen Li,1 Wei Gong1 1Department of Oncology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, 441021, People’s Republic of China; 2Department of Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, 441021, People’s Republic of ChinaCorrespondence: Haolin HuDepartment of Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Jingzhou St 39, Xiangyang 441021, People’s Republic of ChinaTel +86 138 7168 9148Email [email protected]: Cullin 4B (CUL4B) is a member of the cullin ubiquitin-ligase family, which participates in proteolysis. Aberrant CUL4B expression has been shown in many malignancies. This study aimed to elucidate oncogenic role of CUL4B in gastric cancer (GC).Methods: CUL4B expression in GC tissues was examined by RT-PCR and immunohistochemistry. The proliferation, invasion and tumorigenicity of GC cells with CUL4B overexpression or knockdown were evaluated.Results: CUL4B expression significantly increased in GC tissues, and was correlated to UICC stage and differentiation of GC, as well as poor overall survival and disease-free survival. Both univariate and multivariate analysis identified CUL4B as an independent predictor for GC patient prognosis. In addition, CUL4B promoted GC cell proliferation and invasion in vitro and tumor formation in vivo.Conclusion: CUL4B is overexpressed to promote GC development and progression. CUL4B is a promising prognostic marker and therapeutic target for GC.Keywords: CUL4B, gastric cancer, biomarker, prognosis
