A One Pot Synthesis of Diketopiperazines via Multicomponent Reactions Based on Isocyanides

Abstract

2,5-DKPs are heterocyclic peptidomimetics, present in nature with high structural diversity, popular in the design of new bioactive molecules with potential application in medicinal chemistry, exhibiting anticancer and antimicrobial properties, among others. Therefore, in the present work, we report the one-pot synthesis of 2,5-DKPs and their links to another heterocycle 1,4-disubstituted 1,2,3-triazole under mild reaction conditions by one-pot process via the sequence IMCR/postransformation/CuAAC with several advantages over previously reported conventional methods.

Keywords

• 2,5-DKP
• isocyanide-based multicomponent reactions (IMCR)
• CuAAC