Journal of Clinical and Diagnostic Research (Apr 2016)

β-Thalassaemia and its Co-existence with Haemoglobin E and Haemoglobin S in Upper Assam Region of North Eastern India: A Hospital Based Study

  • Anju Barhai Teli,
  • Rumi Deori,
  • Sidhartha Protim Saikia,
  • Kalyani Pathak,
  • Rita Panyang,
  • Rashmi Rajkakati

DOI
https://doi.org/10.7860/JCDR/2016/16265.7675
Journal volume & issue
Vol. 10, no. 4
pp. GC01 – GC04

Abstract

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Introduction: β-Thalassaemias are common genetic disorders in the Indian subcontinent and its status has not been well studied in the Upper Assam region of North Eastern India. Aim: The aim of the study was to show the prevalence of β- thalassaemias and its co-existence with Haemoglobin E and Haemoglobin S in the Upper Assam region of North Eastern India. Materials and Methods: A total of 1200 anaemic patients were investigated for β- thalassaemias. Complete Blood Count (CBC) and High Performance Liquid Chromatography (HPLC) were done for screening. Results: Out of 1200 patients screened, 5.83% β-thalassaemia trait, 2.33% compound Hb E/β-Thalassaemia, 1.33% β-thalassaemia major and 0.42% compound Hb S/β- thalassaemia were detected. A high incidence of thalassaemia is found among the people of Upper Assam region of North Eastern India. Conclusion: The only way to prevent the disease is carrier detection and awareness among the people about it.

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