Nature Communications (Mar 2023)

Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses

  • Silu Deng,
  • Wei He,
  • Ai-Yu Gong,
  • Min Li,
  • Yang Wang,
  • Zijie Xia,
  • Xin-Tiang Zhang,
  • Andrew S. Huang Pacheco,
  • Ankur Naqib,
  • Mark Jenkins,
  • Patrick C. Swanson,
  • Kristen M. Drescher,
  • Juliane K. Strauss-Soukup,
  • Michael Belshan,
  • Xian-Ming Chen

DOI
https://doi.org/10.1038/s41467-023-37129-0
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 17

Abstract

Read online

Cryptosporidium parvum virus 1 is a virus harbored by the pathogenic protozoan Cryptosporidium parvum, and whose role in parasite biology and host interactions remains unclear. Here, Deng et al. demonstrate the impact this virus has on host response and infection outcome.